Surveillance of Erythrovirus B19 (B19V) in patients with acute febrile illness suspected of arboviruses in Mato Grosso do Sul state, Brazil.

Autor:	Lichs GGC; Laboratório Central de Saúde Pública de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.; Postgraduate Program in Infectious and Parasitic Diseases, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Fernandez ZDC; Fundação Oswaldo Cruz, Fiocruz Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., do Nascimento VA; Núcleo de Vigilância de Vírus Emergentes, Reemergentes ou Negligenciados, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil., Alcantara DMC; Fundação Oswaldo Cruz, Fiocruz Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Lemos EF; Universidade Estadual de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Carvalho CME; Universidade Católica Dom Bosco, Campo Grande, Mato Grosso do Sul, Brazil., Demarchi LHF; Laboratório Central de Saúde Pública de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Gonçalves CCM; Postgraduate Program in Infectious and Parasitic Diseases, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.; Secretaria de Estado de Saúde de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Naveca FG; Núcleo de Vigilância de Vírus Emergentes, Reemergentes ou Negligenciados, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil.; Laboratório de Arbovírus e Vírus Hemorrágicos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil., Favacho ARM; Postgraduate Program in Infectious and Parasitic Diseases, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.; Fundação Oswaldo Cruz, Fiocruz Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2024 Jul 18; Vol. 15, pp. 1417434. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).
DOI:	10.3389/fmicb.2024.1417434
Abstrakt:	Introduction: Human Erythrovirus (parvovirus) B19 infection can produce symptoms similar to those produced by Dengue, Chikungunya, and Zika viruses, making clinical diagnosis difficult. The importance of erythrovirus B19 in human pathology has been increased and reported in numerous studies published globally. Methods: The B19V infection was investigated by real-time PCR in sera samples from patients with signs and symptoms related to classic arboviral symptoms. This study was conducted to provide information on the genetic diversity of Human Erythrovirus B19 (B19V) circulating in the state of Mato Grosso do Sul, Midwest region of Brazil, from 2017 to 2022. A total of 773 sera samples of patients with negative diagnostic results for Dengue, Chikungunya, and Zika, during the study period were analyzed. Results: Erythrovirus DNA was found in 10.6% (82/773) of patients, among them 10 were pregnant women. Four samples were completely sequenced, and the other five partially, to genotype by phylogenetic reconstruction. All samples belong to worldwide dispersed genotype 1, subgenotype 1a. Discussion: The findings of the study demonstrate the importance of including B19V in differential laboratory diagnosis for epidemiological purposes and appropriate patient management. The diagnosis for B19V should be performed, particularly among pregnant women, immunocompromised patients, and individuals with hemolytic diseases, given that the infection is more severe in these cases. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Lichs, Fernandez, Nascimento, Alcantara, Lemos, Carvalho, Demarchi, Gonçalves, Naveca and Favacho.)
Databáze:	MEDLINE
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