HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients.

Autor: Andreani M; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Mariotti F; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Pira A; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Locatelli F; Università Cattolica del Sacro Cuore, Rome, Italy.; Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Testa G; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Battarra M; Laboratorio di Immunogenetica dei Trapianti, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Caputi P; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Scarabello A; Dermatology Unit, National Institute for Infectious Diseases IRCCS - L. Spallanzani, Rome, Italy., Bellei B; Laboratory of Cutaneous Physiopathology and Integrated Center for Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, Rome, Italy., Campli CD; Department of Vascular Surgery, Limb Salvage and Diabetic Foot, IDI-IRCCS, Rome, Italy., Collina MC; Department of Vascular Surgery, Limb Salvage and Diabetic Foot, IDI-IRCCS, Rome, Italy., Esposito I; Institute of Dermatology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Giampetruzzi AR; Dermatology Clinic, IDI-IRCCS, Rome, Italy., Didona B; Rare Diseases Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy., Pitocco D; Università Cattolica del Sacro Cuore, Rome, Italy.; Diabetology Unit, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Simone C; Università Cattolica del Sacro Cuore, Rome, Italy.; Institute of Dermatology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Zenzo GD; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.
Jazyk: angličtina
Zdroj: HLA [HLA] 2024 Aug; Vol. 104 (2), pp. e15616.
DOI: 10.1111/tan.15616
Abstrakt: Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: