Whether unplanned excision on synovial sarcoma will influence the prognosis? An retrospective analysis of prognostic factors in 54 synovial sarcoma cases at a single center.

Autor: Guo Q; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China.; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China., Yang Z; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China. 2200013@zju.edu.cn.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China. 2200013@zju.edu.cn.; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China. 2200013@zju.edu.cn.; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China. 2200013@zju.edu.cn., Wang K; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China., Wu J; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China., Liu B; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China.; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China., Lin N; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China.; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China., Tao H; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China.; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China., Ye Z; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University, No.1504 of Jiang Hon Road, BinJiang District, Hangzhou, 310000, Zhejiang Province, China.; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, Zhejiang Province, China.; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, 310000, Zhejiang Province, China.
Jazyk: angličtina
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2024 Aug 02. Date of Electronic Publication: 2024 Aug 02.
DOI: 10.1007/s12094-024-03643-w
Abstrakt: Objective: In this study, we examined the reason and prognosis of unplanned excision on synovial sarcoma.
Methods: We retrospectively analyzed 54 patients diagnosed with synovial sarcoma between March 2013 and February 2021, including 26 cases of unplanned excision surgery. Patients were divided into two groups based on whether they underwent unplanned excision. Then, factors such as gender, age, tumor size, tumor location, American Joint Committee on Cancer (AJCC) staging, unplanned excision, time of onset, duration of disease, radiotherapy, chemotherapy, amputation, local recurrence factors, and death were statistically evaluated.
Results: The results of a multivariate analysis revealed that the AJCC staging is an independent factor for patient prognosis. When patients were divided into two groups, those who had undergone unplanned excision and those who had not, statistical analysis revealed that there was no difference of survival between two groups, but tumor size and AJCC staging had statistical difference. To further explore the influences of unplanned excision, we performed propensity score analysis with 1:1 matching using the nearest neighbor matching method to balance the covariates between the two groups. There was no difference of survival between two groups after propensity score matching.
Conclusion: Unplanned excision is commonly performed in synovial sarcoma and do not impact the prognosis after extensive resection.
(© 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).)
Databáze: MEDLINE
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