Opioid use disorder risk alleles in self-reported assigned African American/Afro-Caribbean and European biogeographical genetic ancestry groups and in males and females.

Autor: Sprague JE; Bowling Green State University, The Ohio Attorney General's Center for the Future of Forensic Science, Bowling Green, OH, USA. jesprag@bgsu.edu., Freiermuth CE; Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA.; Center for Addiction Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Lambert J; College of Nursing, University of Cincinnati, Cincinnati, OH, USA., Braun R; Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA., Frey JA; Department of Emergency Medicine, The Ohio State University, Columbus, OH, USA., Bachmann DJ; Department of Emergency Medicine, The Ohio State University, Columbus, OH, USA., Bischof JJ; Department of Emergency Medicine, The Ohio State University, Columbus, OH, USA., Beaumont L; Department of Pharmaceutical Sciences and Pharmacogenomics, College of Pharmacy, Natural and Health Sciences, Manchester University, Fort Wayne, IN, USA., Lyons MS; Department of Emergency Medicine, The Ohio State University, Columbus, OH, USA., Pantalon MV; Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA., Punches BE; Department of Emergency Medicine, The Ohio State University, Columbus, OH, USA.; College of Nursing, The Ohio State University, Columbus, OH, USA., Ancona R; Washington University School of Medicine, St. Louis, MO, USA., Kisor DF; Department of Pharmaceutical Sciences and Pharmacogenomics, College of Pharmacy, Natural and Health Sciences, Manchester University, Fort Wayne, IN, USA.
Jazyk: angličtina
Zdroj: The pharmacogenomics journal [Pharmacogenomics J] 2024 Aug 01; Vol. 24 (4), pp. 23. Date of Electronic Publication: 2024 Aug 01.
DOI: 10.1038/s41397-024-00337-y
Abstrakt: The influence of genetic variants related to opioid use disorder (OUD) was evaluated using multiple logistic regression analysis in self-reported assigned African American/Afro-Caribbean and European biogeographical ancestry groups (BGAGs) and by sex. From a sample size of 1301 adult patients (>18 years of age) seen in emergency departments of three medical centers in Ohio, six variants were found to be associated with OUD. Two of the variants, rs2740574 (CYP3A4) and rs324029 (DRD3), were included in the analysis having met criteria of at least five subjects for each BGAG, variant carrier status, and OUD status combinations. Variant carriers in the African/Afro-Caribbean BGAG had slightly lower predicted probabilities of OUD. Variant carriers in the European BGAG had slightly higher predicted probabilities of OUD. Relative to sex, all the six variants met evaluation criteria (five subjects for all sex, variant, and OUD status combinations). No statistically significant interactions were found between a given variant, BGAGs and sex. Findings suggest variant testing relative to OUD risk can be applied across BGAGs and sex, however, studies in larger populations are needed.
(© 2024. The Author(s).)
Databáze: MEDLINE
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