Direct effects of heroin and methadone on T cell function.

Autor: Ninnemann A; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Germany. Electronic address: anne.ninnemann@uk-essen.de., Hock K; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Germany., Luppus S; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Germany., Scherbaum N; Department of Psychiatry and Psychotherapy, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Temme C; Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Germany., Buer J; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Germany., Westendorf AM; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Germany., Hansen W; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Germany.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2024 Oct 25; Vol. 140, pp. 112736. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1016/j.intimp.2024.112736
Abstrakt: Opioid addiction presents a relevant health challenge, with chronic heroin use linked to detrimental effects on various aspects of physical, mental, and sociological health. Opioid maintenance therapy (OMT), particularly using methadone, is the primary treatment option for heroin addiction. Previous studies using blood samples from current heroin addicts and OMT patients have shown immunomodulatory effects of heroin and methadone on T cell function. However, various additional factors beyond heroin and methadone affect these results, including the consumption of other substances, a stressful lifestyle, comorbid psychological and somatic disorders, as well as additional medications. Therefore, we here investigated the direct effects of heroin and methadone on purified human T cells in vitro. Our results reveal that both, heroin and methadone directly suppress Tcell activation and proliferation. Strikingly, this inhibitory effect was markedly stronger in the presence of methadone, correlating with a decrease in secretion of pro-inflammatory cytokines. While heroin did not interfere with the in vitro differentiation and expansion of regulatory Tcells (Tregs), methadone significantly impaired the proliferation of Tregs. Overall, our findings suggest a direct inhibitory impact of both opioids on effector T cell function in vitro, with methadone additionally interfering with Treg induction and expansion in contrast to heroin.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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