Clinical and laboratory characteristics and outcome predictors of cerebral venous sinus thrombosis in a referral neurology hospital in Bangladesh.

Autor:	Moniruzzaman M; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Been Sayeed SKJ; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Das SC; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Mostafa MG; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Rashid MB; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Mahmud R; Department of Neurology, Dhaka Medical College Hospital, Dhaka, Bangladesh., Akhter M; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Mehzabin R; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Hossain SMR; Stroke Unit, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh., Rahman MM; Department of Medicine, Popular Medical College Hospital, Dhaka, Bangladesh.
Jazyk:	angličtina
Zdroj:	The Journal of international medical research [J Int Med Res] 2024 Aug; Vol. 52 (8), pp. 3000605241266550.
DOI:	10.1177/03000605241266550
Abstrakt:	Objective: We aimed to describe clinical and laboratory characteristics and determine the predictors of outcome in patients with cerebral venous sinus thrombosis. Methods: This prospective study was conducted over 2 years among hospitalized patients with cerebral venous sinus thrombosis. Patient outcome was assessed using the Modified Rankin Scale (mRS) score at 3 months. Outcome predictors were identified using logistic regression analysis. Results: Eighty-one patients were included in this study. The median mRS outcome at 3 months was 1 (interquartile range 1-3). Poor outcomes were observed in 27.2% of patients, and the mortality rate was 9.8%. Factors associated with poor outcomes were age >60 years (relative risk [RR] 5.1), hemiparesis (RR 5.4), altered level of consciousness (RR 7.1), and transverse sinus involvement (RR 1.1). In general, mRS scores were not associated with D-dimer levels (RR 2.4). However, older patients with elevated D-dimer levels showed a significant association with poor outcomes (1.6) according to mRS scores. Conclusion: Older age, hemiparesis, and altered consciousness levels were independent predictors of poor outcomes in patients with cerebral venous sinus thrombosis. High D-dimer level showed no association with functional disability, except in older patients. Competing Interests: Declaration of conflicting interestThe authors declare that there is no conflict of interest.
Databáze:	MEDLINE
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