| Autor: |
Moura MT; Departamento de Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal da Paraíba-UFPB, João Pessoa, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Cellular reprogramming [Cell Reprogram] 2024 Aug; Vol. 26 (4), pp. 120-123. Date of Electronic Publication: 2024 Aug 01. |
| DOI: |
10.1089/cell.2024.0048 |
| Abstrakt: |
Cloning by somatic cell nuclear transfer (SCNT) remained challenging for Rhesus monkeys, mostly due to its low efficiency and neonatal death. Genome-scale analyses revealed that monkey SCNT embryos displayed widespread DNA methylation and transcriptional alterations, thus including loss of genomic imprinting that correlated with placental dysfunction. The transfer of inner cell masses (ICM) from cloned blastocysts into ICM-depleted fertilized embryos rescued placental insufficiency and gave rise to a cloned Rhesus monkey that reached adulthood without noticeable abnormalities. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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