Inflammatory Profile of Chronic Rhinosinusitis With Nasal Polyp Patients in Brazil: Multicenter Study.

Autor: Romano FR; Department of Ophtalmology, Otorhinolaryngology and Head and Neck Surgery, University of Sao Paulo, FMRP-USP, São Paulo, Brazil., Valera FCP; Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeirão Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Fornazieri MA; Department of Otorhinolaryngology, State University of Londrina and PUC-Paraná, Paraná, Brazil., Lopes NMD; Department of Otorhinolaryngology, Grupo de Excelência Médica, State University of Londrina and PUC-Paraná, Paraná, Brazil., Miyake MM; Department of Otorhinolaryngology at Santa Casa de Misericórdia Hospital of São Paulo, FMRP-USP, São Paulo, Brazil., Dolci RLL; Department of Otorhinolaryngology at Santa Casa de Misericórdia Hospital of São Paulo, São Paulo, Brazil., Nakanishi M; Medical School Graduate Program, University of Brasília, Brasília, Brazil., Freire GSM; Department of Otorhinolaryngology, Medical Sciences University of Brasilia, Brasilia, Brazil., Sakano E; Department of Ophthalmology/Otorhinolaryngology of the Science Medical School of Sao Paulo State University, Sao Paulo, Brazil., Toro MDC; Department of Otolaryngology, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil., Kosugi EM; Department of Otorhinolaryngology, Head and Neck Surgery at Paulista School of Medicine, Federal University of Sao Paulo, São Paulo, Brazil., Gregorio LL; Department of Otorhinolaryngology, Universidade Federal de São Paulo, São Paulo, Brazil., Dos Santos MCJ; Department of Otorhinolaryngology, Catholic University of Parana, Parana, Brazil., Murata J; Department of Otorhinolaryngology, Eco Medical Center, Curitiba, Parana, Brazil., Fernandes AM; Department of Otorhinolaryngology and Head and Neck Surgery, Famerp, São José do Rio Preto, São Paulo, Brazil., Moras LL; Department of Otorhinolaryngology and Head and Neck Surgery, Famerp, São José do Rio Preto, São Paulo, Brazil., Avelino MAG; Department at Goiás Federal University, Goiás Federal University, Goiás, Brazil., Camargo LA; Department of Otolaryngology, Federal University of Goias, Goias, Brazil., Lessa MM; Department of Otorhinolaryngology, Otorhinolaryngology of the Federal University of Bahia Medical School, Salvador, Bahia, Brazil., Almeida LDC; Department of Otorhinolaryngology, Medical Sciences Federal University of Bahia Medical School, Salvador, Bahia, Brazil., Roithmann R; Otolaryngology Department of Otolaryngology-Head and Neck Surgery, Universidade Luterana do Brasil, Porto Alegre, Brazil.; Department of Otolaryngology-Head and Neck Surgery Mount Sinai Hospital, Toronto, Canada., Redeker N; Department of Otolaryngology-Head and Neck Surgery, Universidade Luterana do Brazil, Rio Grande do Sul, Brazil., Tepedino MS; Division of Clinical Otorhinolaryngology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Policlínica de Botafogo, Rio de Janeiro, Brazil., Vianna PM; Department of Otorhinolaryngology, Medical Residency Program of Otorhinolaryngology at Army Central Hospital-RJ, Rhinology and Skull Base Endoscopic Surgery Team at HUPE-UERJ, Rio de Janeiro, Brazil., Piltcher OB; Department of Otorhinolaryngology, School of Medicine, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil., Meotti CD; Department of Otorhinolaryngology, Hospital de Clinicas de Porto Alegre, Surgical Sciences at Universidade Federal do Rio Grande do Sul, Rhinology at Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Bezerra TFP; Department of Otorhinolaryngology, Federal University of Pernambuco, Pernambuco, Brazil., Voegels RL; Department of Otorhinolaryngology, University of São Paulo, São Paulo, Brazil., de Mendonça Pilan RR; Department of Otorhinolaryngology, University of São Paulo, São Paulo, Brazil., Batista Murashima AA; Department of Otorhinolaryngology, University of São Paulo, São Paulo, Brazil., da Silva LECM; Department of Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeirão Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Arruda E; Department of Cell and Molecular Biology, Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Garcia DM; Department of Otorhinolaryngology, University of São Paulo, São Paulo, Brazil., Tamashiro E; Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeirão Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Anselmo-Lima W; Department of Ophthalmology, Otorhinolaryngology, Head and Neck Surgery, Ribeirão Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2024 Aug 01. Date of Electronic Publication: 2024 Aug 01.
DOI: 10.1002/ohn.904
Abstrakt: Objectives: To determine the inflammatory profile of CRSwNP in Brazil and characterize the subgroups of CRSwNP patients in this population through cluster analysis.
Study Design: Multicenter cross-sectional study involving 15 centers representing different regions of Brazil.
Subjects and Methods: Clinical data of 166 patients and 80 controls, aged 18 to 70 years old, number of surgeries for CRS, history of asthma and aspirin sensitivity, and Lund-Mackay scores on CT scans. During nasal endoscopy, we obtained the Lund-Kennedy scores and collected 2 samples of nasal polyps: one for eosinophil and neutrophil tissue counts and one to quantify different cytokines.
Results: 79.6% of our patients had 10 or more eosinophils/HPF. CRSwNP groups exhibited significantly lower concentrations of TNF-alpha and significantly higher concentrations of IFN-gamma, CCL11/Eotaxin, CCL24/Eotaxin-2/MPIF-2, and CCL26/Eotaxin-3 versus the control group (Kruskal-Wallis test). Comparison between CRSwNP groups (≥10 vs <10 eosinophils/HPF) showed no difference in cytokine concentration (Mann-Whitney test). Hierarchical clustering and PCA according to cytokine concentrations revealed 2 main Clusters, with a significantly higher concentration of all cytokines in Cluster 1 (n = 35) than in Cluster 2 (n = 121), except IL-6 and IL-33 (Mann-Whitney test). According to ROC curve analysis the best cut-off to differentiate the 2 clusters was 43 eosinophils/HPF. The group with ≥43 presented a higher prevalence of men and a higher Lund-Mackay score (Mann-Whitney test).
Conclusions: CRSwNP patients in Brazil present mixed inflammation, with 2 distinct groups (high and low inflammatory pattern) that can be distinguished by tissue eosinophilia of ≥43 eosinophils/HPF cut-off in nasal polyps.
(© 2024 American Academy of Otolaryngology–Head and Neck Surgery Foundation.)
Databáze: MEDLINE
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