Glucose disturbances in very low-birthweight infants-Results from the prospective LIGHT study.

Autor: Zamir I; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden., Stoltz Sjöström E; Department of Food, Nutrition and Culinary Science, Umeå University, Umeå, Sweden., van den Berg J; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden., Berhan Y; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden., Naumburg E; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden., Domellöf M; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Dec; Vol. 113 (12), pp. 2556-2563. Date of Electronic Publication: 2024 Aug 01.
DOI: 10.1111/apa.17370
Abstrakt: Aim: To describe glucose homeostasis disturbances (dysglycaemia) in very low-birthweight infants (<1500 g) during the admission period and explore associated risk factors.
Methods: The LIGHT (very low-birthweight infants - glucose and hormonal profile over time) study was a prospective observational cohort study that included 49 very low-birthweight infants admitted to the tertiary neonatal intensive care unit in Umeå, Sweden, during 2016-2019. All glucose concentrations (n = 3515) sampled during the admission period were registered.
Results: Hyperglycaemia >10 mmol/L and hypoglycaemia <2.6 mmol/L were registered in 63% and 55% of the infants, respectively. Onset of dysglycaemia occurred almost exclusively in the first postnatal week. Hyperglycaemia followed 15% of corticosteroid doses given; all were preceded by pre-existing hyperglycaemia. Pre-existing hyperglycaemia was found in 66.7% of hyperglycaemic infants who received inotrope treatment. Upon commencement, 72.5% of antimicrobial treatments given were neither preceded nor followed by hyperglycaemia.
Conclusion: Dysglycaemia was common in very low-birthweight infants. Daily means of glucose concentrations seemed to follow a postmenstrual age-dependent pattern, decreasing towards term age suggesting a postmenstrual age-dependent developmental mechanism. The primary mechanism causing hyperglycaemia was independent of sepsis, and corticosteroid and inotrope treatments. No hypoglycaemia was registered during ongoing insulin treatment.
(© 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
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