Adverse effect of smoking on surgical site infection following ankle and calcaneal fracture fixation: a meta-analysis.

Autor:	Tran DNA; The International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Nguyen BTT; The International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Nguyen TT; Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam., Chen YP; Department of Orthopedics, Taipei Municipal Wan-Fang Hospital, Taipei, Taiwan.; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Kuo YJ; Department of Orthopedics, Taipei Municipal Wan-Fang Hospital, Taipei, Taiwan.; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Jazyk:	angličtina
Zdroj:	EFORT open reviews [EFORT Open Rev] 2024 Aug 01; Vol. 9 (8), pp. 817-826. Date of Electronic Publication: 2024 Aug 01.
DOI:	10.1530/EOR-23-0139
Abstrakt:	Purpose: Studies have reported conflicting findings on the relationship between smoking and surgical site infection (SSI) post fixation for ankle and calcaneal fractures. This meta-analysis explored the effect of smoking on SSI incidence following open reduction and internal fixation (ORIF) of these fractures. Methods: Full-text studies on smoking's influence on post-ORIF SSI rates for closed ankle and calcaneal fractures were sourced from the PubMed, Embase, and Cochrane databases, with no consideration given to language or publication date. Study quality was appraised using the Newcastle-Ottawa Scale. Odds ratios (OR) and the corresponding 95% CIs were determined using random-effects models. This meta-analysis adhered to the PRISMA guidelines and was registered with PROSPERO (CRD42023429372). Results: The analysis incorporated data from 16 cohort and case-control studies, totaling 41 944 subjects, 9984 of whom were smokers, with 956 SSI cases. Results indicated smokers faced a higher SSI risk (OR: 1.62; 95% CI: 1.32-1.97, P < 0.0001) post ORIF, with low heterogeneity (I 2 = 26%). Smoking was identified as a significant deep SSI risk factor (OR: 2.09; 95% CI: 1.42-3.09; P = 0.0002; I 2 = 31%). However, the subgroup analysis revealed no association between smoking and superficial SSI (OR: 1.05; 95% CI: 0.82-1.33; P = 0.70; I 2 = 0%). Conclusion: Smoking is associated with increased SSI risk after ORIF for closed ankle and calcaneus fractures. Although no clear link was found between superficial SSI and smoking, the data underscore the negative influence of smoking on deep SSI incidence.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu