Specialized Metabolites from the Husks of Rice Oryza Sativa L. and their Biological Activities.
| Autor: | Zhang XY; College of Pharmacy, Nantong University, Nantong, 226001, P. R. China., Ge C; College of Pharmacy, Nantong University, Nantong, 226001, P. R. China.; The First People's Hospital of Kunshan, Jiangsu, 215300, P. R. China., Zhang AJ; College of Pharmacy, Nantong University, Nantong, 226001, P. R. China., Wu SX; College of Pharmacy, Nantong University, Nantong, 226001, P. R. China., Yang M; College of Pharmacy, Nantong University, Nantong, 226001, P. R. China., Huang L; Department of Pharmacy, First People's Hospital of Yancheng, Yancheng, 224006, P. R. China., Li JL; College of Pharmacy, Nantong University, Nantong, 226001, P. R. China. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2024 Nov; Vol. 21 (11), pp. e202401640. Date of Electronic Publication: 2024 Sep 19. |
| DOI: | 10.1002/cbdv.202401640 |
| Abstrakt: | Rice (Oryza sativa L.) husk harbors a substantial proportion of biological metabolites, as one of the most plentiful agriculture by-products in rice milling process, rice husk remains poorly utilized. As a continuing search for potential bioactive molecules from the husk of rice, a totally of twelve components (1-12), including six sterol ferulates (1-6), one flavonoid (7), one dipeptide (8), and four phenylpropanoid derivatives (9-12) were obtained. All the chemical structures were elucidated based on comprehensive spectroscopic data. Wherein, compounds 1 and 2 were yield as previous undescribed metabolites, and the comprehensive NMR data for compounds 3 and 4 were first presented in its entirety. Motivated by the similarity of the structural motifs of components 1-6 to that of reported sterol ferulates, the antioxidant and anti-inflammatory effects for compounds 1-6 were evaluated in vitro. Among them, compounds 5/6 had a significant antioxidant activity compare to that of vitamin E in both DPPH and reducing power assay up to the concentration 40 μg/ml; while compounds 1 and 2 exhibited weak suppressive effect on the production of nitric oxide, with the IC (© 2024 Wiley-VHCA AG, Zurich, Switzerland.) |
| Databáze: | MEDLINE |
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