Significance of p16 in Site-Specific Human Papillomavirus-Positive and Negative Head and Neck Squamous Cell Carcinoma (HNSCC).

Autor:	Priyatha V; Internal Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND., Gupta H; Medicine, American University of the Caribbean, Cupecoy, SXM., Narsapuram P; Medicine, Kamineni Institute of Medical Sciences, Narketpally, IND., Ahmed F; Internal Medicine, Bahria University Medical and Dental College, Karachi, PAK., Alhussain H; Epidemiology and Public Health, King Fahad Hospital Hofuf, Ministry of Health, Al-Ahsa, SAU., Arfa A; Medicine, Shadan Institute of Medical Sciences Teaching Hospital and Research Centre, Hyderabad, IND., Taha Hussain M; Medicine, Shadan Institute of Medical Sciences Teaching Hospital and Research Centre, Hyderabad, IND., Abyad Eltayeb AA; Medicine, Bashaier Hospital, Khartoum, SDN., Abdul Mateen M; Internal Medicine, Shadan Institute of Medical Sciences Teaching Hospital and Research Centre, Hyderabad, IND., Prajjwal P; Neurology, Bharati Vidyapeeth University Medical College, Pune, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 01; Vol. 16 (7), pp. e63594. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024).
DOI:	10.7759/cureus.63594
Abstrakt:	Background: Head and neck squamous cell carcinoma (HNSCC) represents a group of cancers characterized by diverse origins and changing epidemiological patterns. The significance of high-risk human papillomavirus (HPV) infection in certain HNSCC cases has gained attention for its impact on the disease's behavior. Our current research focused on exploring the importance of using p16 as an HNSCC biomarker, particularly in the context of HPV infection, assessing its value in prognosis, and examining its variation across different tumor locations. Materials and Methods: A retrospective analysis was carried out on 100 HNSCC patients from a tertiary care center, with particular attention paid to p16 expression, HPV status, clinic-pathological characteristics, and prognosis. HPV was detected using polymerase chain reaction (PCR) techniques, and p16 expression was evaluated by immunohistochemistry. According to the ethical guidelines outlined in the Declaration of Helsinki, multivariate analysis assessed the prognostic value of p16. Results: Our analysis demonstrated a significant correlation between HPV status and p16 expression in HNSCC cases. A vast majority of 58 (96.7%) HPV-+ cases exhibited p16 overexpression, contrasting sharply with only two (5%) in the HPV-- group. Patients with tumors that were both p16+ and HPV+ exhibited more favorable overall survival rates. In contrast, those with p16- and HPV- tumors experienced the poorest survival outcomes. Notably, having a p16-- status in HPV+ cases emerged as an independent factor for reduced survival. Additionally, the study revealed distinct variations in p16 expression based on tumor location, particularly within the oropharyngeal area. Conclusion: The study established that p16 is a dependable indication for the existence of HPV in HNSCC and highlights its significant role as a prognostic factor, particularly in cases that are p16-- yet HPV-+. These findings underscore the importance of adopting site-specific treatment approaches in HNSCC management and contribute to a deeper understanding of p16's role in the disease, thereby aiding in more effective risk assessment and treatment planning. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Shadan Institute of Medical Sciences issued approval IRB/SIMS/03/25314/2023. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Priyatha et al.)
Databáze:	MEDLINE
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