Serum IL-6 as a Surrogate Biomarker of Post-operative Complications in Invasive Orthopaedic Surgeries: A Prospective Observational Study.

Autor: Laishram K; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India., Borgohain B; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India., Laishram A; Department of Biochemistry, NEIGRIHMS, Shillong, Meghalaya 793018 India., Khonglah TG; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India., Ruram AA; Department of Biochemistry, NEIGRIHMS, Shillong, Meghalaya 793018 India., Debbarma S; Department of Orthopaedics and Trauma, NEIGRIHMS, Shillong, Meghalaya 793018 India.
Jazyk: angličtina
Zdroj: Indian journal of orthopaedics [Indian J Orthop] 2024 Jun 25; Vol. 58 (8), pp. 1153-1158. Date of Electronic Publication: 2024 Jun 25 (Print Publication: 2024).
DOI: 10.1007/s43465-024-01195-3
Abstrakt: Background: Interleukin-6 (IL-6) is a cytokine released in response to tissue injury. Elevated serum IL-6 levels in trauma patients have been linked with increased risk of complications such as inapparent hypoxia (SpO 2  < 94%), acute respiratory distress syndrome, fat embolism syndrome (FES), systemic inflammatory response syndrome, multiple organ dysfunction syndrome and sepsis. This study aims to determine the role of serum IL-6 as surrogate biomarker of post-operative complications after invasive orthopaedic surgeries.
Methods: Thirty-seven adults between 18 and 65 years of age undergoing invasive orthopaedic surgeries were included in this hospital-based study. Serum IL-6 levels were estimated serially in the pre-operative period, after 24 h and 7 days post-operatively. Cases were monitored for post-operative complications.
Results: Serum IL-6 levels showed maximum rise in the first 24 h post-operatively especially among older patients (> 60 years). Older patients undergoing bipolar hemiarthroplasty for neck of femur fracture showed highest median post-operative IL-6 level of 258 pg/ml. Serum IL-6 level > 130 pg/ml measured 24 h after surgery was predictive of post-operative complications (sensitivity of 75%). Among the cases with post-operative complications, inapparent hypoxia was the most common complication/event observed. Cases with sub-clinical FES had highest level of serum IL-6 in first 24 h following surgery with median IL-6 level of 300 pg/ml (range 155-444 pg/ml).
Conclusion: Monitoring serum IL-6 level may help in both anticipation and early detection of post-operative complications in patients undergoing invasive orthopaedic surgeries; potentially enhancing patient safety.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest.
(© Indian Orthopaedics Association 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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