Translational insights into the hormetic potential of carbon dioxide: from physiological mechanisms to innovative adjunct therapeutic potential for cancer.
Autor: | Gaspary JFP; Postgraduate Program in Production Engineering, Federal University of Santa Maria, Santa Maria, Brazil., Edgar L; Elastro Crete, LLC. Research and Development Department, Veyo, UT, United States., Lopes LFD; Department of Administrative Sciences, Federal University of Santa Maria, Santa Maria, Brazil., Rosa CB; Production Engineering Department, Federal University of Santa Maria, Santa Maria, Brazil., Siluk JCM; Production Engineering Department, Federal University of Santa Maria, Santa Maria, Brazil. |
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Jazyk: | angličtina |
Zdroj: | Frontiers in physiology [Front Physiol] 2024 Jul 17; Vol. 15, pp. 1415037. Date of Electronic Publication: 2024 Jul 17 (Print Publication: 2024). |
DOI: | 10.3389/fphys.2024.1415037 |
Abstrakt: | Background: Carbon dioxide (CO Objectives: This study aims to explore CO2's role in the tumor environment, particularly how its physiological properties and adaptive responses can influence therapeutic strategies. Methods: By applying a structured translational approach using the Work Breakdown Structure method, the study divided the analysis into six interconnected work packages to comprehensively analyze the interactions between carbon dioxide and the tumor microenvironment. Methods included systematic literature reviews, data analyses, data integration for identifying critical success factors and exploring extracellular environment modulation. The research used SMART criteria for assessing innovation and the applicability of results. Results: The research revealed that the human body's adaptability to hypercapnic conditions could potentially inform innovative strategies for manipulating the tumor microenvironment. This could enhance O Conclusion: The study underscores CO Competing Interests: Author LE was employed by Elastro Crete. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Gaspary, Edgar, Lopes, Rosa and Siluk.) |
Databáze: | MEDLINE |
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