Implications of hypocobalaminemia as a negative prognostic marker in juvenile dogs with parvovirus enteritis.

Autor:	Luckschander-Zeller N; Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria., Giani B; Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria., Doulidis PG; Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria., Plickert HD; Tierklinik Parndorf, Parndorf, Austria., Tichy A; Department for Biomedical Sciences, University of Veterinary Medicine of Vienna, Vienna, Austria., Marculescu R; Clinical Institute for Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Schwendenwein I; Central Laboratory, Department for Pathobiology, University of Veterinary Medicine of Vienna, Vienna, Austria., Burgener IA; Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2024 Jul 16; Vol. 11, pp. 1426664. Date of Electronic Publication: 2024 Jul 16 (Print Publication: 2024).
DOI:	10.3389/fvets.2024.1426664
Abstrakt:	Introduction: Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute enteropathies, especially in young dogs. The aim of this study was to investigate the frequency and severity of hypocobalaminemia in young dogs with parvovirus enteritis and evaluation of CBL as a predictor of outcome. Materials and Methods: Thirty client-owned dogs diagnosed with parvovirus infection and thirty healthy controls were enrolled. Clinical, hematological, and biochemical tests, including CBL and serum methylmalonic acid (MMA) concentrations, were assessed. Results: Results indicated a significantly higher prevalence of hypocobalaminemia in dogs with parvovirus enteritis compared to healthy controls, as well as a significant correlation with a disease severity score. Moreover, survivors demonstrated higher CBL concentrations than non-survivors, suggesting an eventual prognostic value of CBL status. However, parenteral CBL supplementation showed no significant effect on serum CBL or MMA concentrations, highlighting potential challenges in CBL uptake at the cellular level. Discussion: Hypocobalaminemia in this population is caused by multiple factors such as reduced nutritional absorption, gastrointestinal losses, and increased metabolic demands. Further research is needed to develop tailored management strategies, evaluate the effectiveness of CBL supplementation, and understand the mechanisms behind hypocobalaminemia in parvovirus infection. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Luckschander-Zeller, Giani, Doulidis, Plickert, Tichy, Marculescu, Schwendenwein and Burgener.)
Databáze:	MEDLINE
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