Dysregulation of myelination-related genes in schizophrenia.

Autor: Bergstrom JJD; Department of Molecular and Cell Biology, UC Berkeley, Berkeley, California, USA., Fu MM; Department of Molecular and Cell Biology, UC Berkeley, Berkeley, California, USA.
Jazyk: angličtina
Zdroj: Journal of neurochemistry [J Neurochem] 2024 Sep; Vol. 168 (9), pp. 2227-2242. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1111/jnc.16152
Abstrakt: Schizophrenic individuals display disrupted myelination patterns, altered oligodendrocyte distribution, and abnormal oligodendrocyte morphology. Schizophrenia is linked with dysregulation of a variety of genes involved in oligodendrocyte function and myelin production. Single-nucleotide polymorphisms (SNPs) and rare mutations in myelination-related genes are observed in certain schizophrenic populations, representing potential genetic risk factors. Downregulation of myelination-related RNAs and proteins, particularly in frontal and limbic regions, is consistently associated with the disorder across multiple studies. These findings support the notion that disruptions in myelination may contribute to the cognitive and behavioral impairments experienced in schizophrenia, although further evidence of causation is needed.
(© 2024 International Society for Neurochemistry.)
Databáze: MEDLINE
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