Auditory Steady-State Responses: Multiplexed Amplitude Modulation Frequencies to Reduce Recording Time.

Autor:	Sonck R; Department of Neurosciences, Research Group Experimental Oto-rhino-laryngology, KU Leuven, Leuven, Belgium.; Grappe Interdisciplinaire de Génoprotéomique Appliquée-Consciousness, Coma Science Group, University of Liège, Liège, Belgium.; Brain Center (C2), University Hospital Center of Liège, Liège, Belgium.; These authors shared first-authorship., Vanthornhout J; Department of Neurosciences, Research Group Experimental Oto-rhino-laryngology, KU Leuven, Leuven, Belgium.; These authors shared first-authorship., Bonin E; Grappe Interdisciplinaire de Génoprotéomique Appliquée-Consciousness, Coma Science Group, University of Liège, Liège, Belgium.; Brain Center (C2), University Hospital Center of Liège, Liège, Belgium., Francart T; Department of Neurosciences, Research Group Experimental Oto-rhino-laryngology, KU Leuven, Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	Ear and hearing [Ear Hear] 2025 Jan-Feb 01; Vol. 46 (1), pp. 24-33. Date of Electronic Publication: 2024 Aug 01.
DOI:	10.1097/AUD.0000000000001552
Abstrakt:	Objectives: This study investigated the efficiency of a multiplexed amplitude-modulated (AM) stimulus in eliciting auditory steady-state responses. The multiplexed AM stimulus was created by simultaneously modulating speech-shaped noise with three frequencies chosen to elicit different neural generators: 3.1, 40.1, and 102.1 Hz. For comparison, a single AM stimulus was created for each of these frequencies, resulting in three single AM conditions and one multiplex AM condition. Design: Twenty-two bilaterally normal-hearing participants (18 females) listened for 8 minutes to each type of stimuli. The analysis compared the signal to noise ratios (SNRs) and amplitudes of the evoked responses to the single and multiplexed conditions. Results: The results revealed that the SNRs elicited by single AM conditions were, on average, 1.61 dB higher than those evoked by the multiplexed AM condition ( p < 0.05). The single conditions consistently produced a significantly higher SNR when examining various stimulus durations ranging from 1 to 8 minutes. Despite these SNR differences, the frequency spectrum was very similar across and within subjects. In addition, the sensor space patterns across the scalp demonstrated similar trends between the single and multiplexed stimuli for both SNR and amplitudes. Both the single and multiplexed conditions evoked significant auditory steady-state responses within subjects. On average, the multiplexed AM stimulus took 31 minutes for the lower bound of the 95% prediction interval to cross the significance threshold across all three frequencies. In contrast, the single AM stimuli took 45 minutes and 42 seconds. Conclusions: These findings show that the multiplexed AM stimulus is a promising method to reduce the recording time when simultaneously obtaining information from various neural generators. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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