Mitigating multiples, less is more: examining trends in multifetal gestation rates with assisted reproductive technology.

Autor: Kim H; Cleveland Clinic Foundation OB/GYN and Women's Health Institute, Reproductive Endocrinology and Infertility, Cleveland, OH, USA., Claffey AJ; Southwestern, Obstetrics and Gynecology, University of Texas, Dallas, TX, USA. andrewjclaffey@gmail.com., Doody KJ; Southwestern, Obstetrics and Gynecology, University of Texas, Dallas, TX, USA.; CARE Fertility, Reproductive Endocrinology and Infertility, Bedford, TX, USA., Doody KM; Southwestern, Obstetrics and Gynecology, University of Texas, Dallas, TX, USA.; CARE Fertility, Reproductive Endocrinology and Infertility, Bedford, TX, USA.
Jazyk: angličtina
Zdroj: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Sep; Vol. 41 (9), pp. 2301-2310. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1007/s10815-024-03208-4
Abstrakt: Purpose: Multifetal gestation (MFG) is much more common in pregnancies that utilize assisted reproductive technologies (ART). We assessed how these rates have changed over the previous decade and the impact on live birth rates (LBR).
Methods: This retrospective cohort study uses the National Summary Reports of the Society for Assisted Reproductive Technology (SART) from 2014 to 2020. Data points included only autologous cycles. The data were divided into five age groups as reported in the database: < 35, 35-37, 38-40, 41-42, and > 42 years old. Descriptive statistics and a two-tailed T-test were used to determine the trends and statistical significance (p < 0.05).
Results: Rates of twin births decreased substantially from 2014 to 2020 for autologous embryo transfers across all age groups and diagnoses. Surprisingly, the overall LBR for autologous IVF cycles decreased at similar rates from 2014 to 2020 in all age groups. The mean number of embryos transferred has dramatically reduced, especially across age groups < 42.
Conclusion: Rates of twin and higher-level gestations have decreased substantially over the past decade; the effect correlates with the increased utilization of eSET and PGT. The cause of infertility did not significantly impact the rate of MFG.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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