Commissioning an ultra-high-dose-rate electron linac with end-to-end tests.
| Autor: | Dai T; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.; Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250000, People's Republic of China., Sloop AM; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America., Ashraf MR; Stanford Radiation Oncology, Palo Alto, CA 94304, United States of America., Sunnerberg JP; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America., Clark MA; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America., Bruza P; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America., Pogue BW; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.; Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, United States of America.; Department of Medical Physics, Wisconsin Institutes for Medical Research, University of Wisconsin, Madison, WI 53705, United States of America., Jarvis L; Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, United States of America.; Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, United States of America., Gladstone DJ; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.; Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, United States of America.; Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, United States of America., Zhang R; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.; Department of Radiation Medicine, New York Medical College, Valhalla, NY 10595, United States of America. |
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| Jazyk: | angličtina |
| Zdroj: | Physics in medicine and biology [Phys Med Biol] 2024 Aug 09; Vol. 69 (16). Date of Electronic Publication: 2024 Aug 09. |
| DOI: | 10.1088/1361-6560/ad69fc |
| Abstrakt: | Objective . The FLASH effect can potentially be used to improve the therapeutic ratio of radiotherapy (RT) through delivery of Ultra-high-dose-rate (UHDR) irradiation. Research is actively being conducted to translate UHDR-RT and for this purpose the Mobetron is capable of producing electron beams at both UHDR and conventional dose rates for FLASH research and translation. This work presents commissioning of an UHDR Mobetron with end-to-end tests developed for preclinical research. Approach . UHDR electron beams were commissioned with an efficient approach utilizing a 3D-printed water tank and film to fully characterize beam characteristics and dependences on field size, pulse width (PW) and pulse repetition frequency (PRF). This commissioning data was used to implement a beam model using the GAMOS Monte Carlo toolkit for the preclinical research. Then, the workflow for preclinical FLASH irradiation was validated with end-to-end tests delivered to a 3D-printed mouse phantom with internal inhomogeneities. Main results. PDDs, profiles and output factors acquired with radiochromic films were precisely measured, with a PRF that showed little effect on the UHDR beam energy and spatial characteristics. Increasing PW reduced the D (© 2024 Institute of Physics and Engineering in Medicine.) |
| Databáze: | MEDLINE |
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