Experimental toothpastes containing β-TCP nanoparticles functionalized with fluoride and tin to prevent Erosive Tooth Wear.

Autor: Weiss GS; Department of Restorative Dentistry, University of São Paulo (USP), School of Dentistry, Av. Prof Lineu Prestes 2227, São Paulo, SP, 05508-000, Brazil., Silva FRO; Material Science and Technology Center, Nuclear and Energy Research Institute (IPEN-CNEN), Av. Prof. Lineu Prestes 2242, São Paulo, SP 05508-000, Brazil., Garcia RM; Department of Restorative Dentistry, University of São Paulo (USP), School of Dentistry, Av. Prof Lineu Prestes 2227, São Paulo, SP, 05508-000, Brazil., Sakae LO; Department of Restorative Dentistry, University of São Paulo (USP), School of Dentistry, Av. Prof Lineu Prestes 2227, São Paulo, SP, 05508-000, Brazil., Viana ÍEL; Department of Comprehensive Care, Division of Operative Dentistry - Tufts University School of Dental Medicine, Boston, MA, USA., Hara AT; Department of Cariology and Operative Dentistry, Indiana University School of Dentistry (IUSD), Indianapolis, IN, USA., Lima LC; Department of Dentistry, Federal University of Juiz de Fora (UFJF), Campus Governador Valadares, MG, 35010-180, Brazil. Electronic address: leonardo.lima@ufjf.br., Scaramucci T; Department of Restorative Dentistry, University of São Paulo (USP), School of Dentistry, Av. Prof Lineu Prestes 2227, São Paulo, SP, 05508-000, Brazil.
Jazyk: angličtina
Zdroj: Journal of dentistry [J Dent] 2024 Oct; Vol. 149, pp. 105273. Date of Electronic Publication: 2024 Jul 29.
DOI: 10.1016/j.jdent.2024.105273
Abstrakt: Objectives: The present study aimed to synthesize toothpastes containing Beta- TriCalcium Phosphate (β-TCP) nanoparticles, functionalized with fluoride and tin, and test their ability to reduce erosive tooth wear (ETW).
Methods: Toothpastes were synthesized with the following active ingredients: 1100 ppm of fluoride (as sodium fluoride, F - ), 3500 ppm of tin (as stannous chloride, Sn 2+ ), and 800 ppm of β-TCP (Sizes a - 20 nm; and b - 100 nm). Enamel specimens were randomly assigned into the following groups (n = 10): 1. Commercial toothpaste; 2. Placebo; 3 F - ; 4. F - + β-TCP a ; 5. F - + β-TCP b ; 6. F - + Sn 2+ ; 7. F - + Sn 2+ + β-TCP a and 8. F - + Sn 2+ + β-TCP b . Specimens were subjected to erosion-abrasion cycling. Surface loss (in µm) was measured by optical profilometry. Toothpastes pH and available F - were also assessed.
Results: Brushing with placebo toothpaste resulted in higher surface loss than brushing with F - (p = 0.005) and F - + β-TCP b (p = 0.007); however, there was no difference between F - and F - + β-TCP b (p = 1.00). Commercial toothpaste showed no difference from Placebo (p = 0.279). The groups F - , F - + β-TCP a , F - + β-TCP b , F - + Sn 2+ , F - + Sn 2+ + β-TCP a and F - + Sn 2+ + β-TCP b were not different from the commercial toothpaste (p > 0.05). Overall, the addition of β-TCP reduced the amount of available fluoride in the experimental toothpastes. The pH of toothpastes ranged from 4.97 to 6.49.
Conclusions: Although toothpaste containing β-TCP nanoparticles protected enamel against dental erosion-abrasion, this effect was not superior to the standard fluoride toothpaste (commercial). In addition, the functionalization of β-TCP nanoparticles with fluoride and tin did not enhance their protective effect.
Clinical Significance: Although β-TCP nanoparticles have some potential to control Erosive Tooth Wear, their incorporation into an experimental toothpaste appears to have a protective effect that is similar to a commercial fluoride toothpaste.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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