Acetylsalicylic acid inhibition of the lipoxygenase pathway: Implications for HIV prevention.

Autor: Kowatsch MM; Laboratory of Viral Immunology, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada., Winter T; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada., Oyugi J; Laboratory of Viral Immunology, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya., Kimani J; Laboratory of Viral Immunology, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Partners for Health and Development in Africa, Nairobi, Kenya; University of Nairobi Institute for Tropical and Infectious Diseases, University of Nairobi. Nairobi, Kenya., Lajoie J; Laboratory of Viral Immunology, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya., Aukema HM; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada., Fowke KR; Laboratory of Viral Immunology, Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Partners for Health and Development in Africa, Nairobi, Kenya; Department of Community Health Science, University of Manitoba, Winnipeg, MB, Canada. Electronic address: keith.fowke@umanitoba.ca.
Jazyk: angličtina
Zdroj: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2024 Oct; Vol. 174, pp. 106878. Date of Electronic Publication: 2024 Jul 29.
DOI: 10.1016/j.prostaglandins.2024.106878
Abstrakt: Background: 1.5 million new HIV infections occurred in 2021, suggesting new prevention methods are needed. Inflammation increases the risk for HIV acquisition by attracting HIV target cells to the female genital tract (FGT). In a pilot study, acetylsalicylic acid (ASA/Aspirin) decreased the proportion of FGT HIV target cells by 35 %. However, the mechanism remains unknown.
Methods: Women from Nairobi, Kenya took low-dose ASA (81 mg) daily for 6-weeks. Free oxylipins in the plasma were quantified by high-performance liquid chromatography-tandem mass spectroscopy.
Results: Oxylipins from 9 fatty acid substrates were detected, with more than one analyte from 4 substrates reduced post-ASA. Summary analysis found ASA downregulated cyclooxygenase and lipoxygenase but not cytochrome P450 activity with a lower n-6/n-3 oxylipin profile, reflecting reduced inflammation post-ASA.
Conclusions: Inflammation is associated with increased lipoxygenase activity and HIV risk. Our data suggests ASA reduces inflammation through downregulation of oxylipins. Understanding how ASA reduces inflammation may lead to novel HIV prevention approaches.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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