Selenium biomarkers and miR-7-5p in overweight/obese women.

Autor: Alves HPM; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil. Electronic address: higor.paiva.700@ufrn.edu.br., Duarte GBS; Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 14 - Butantã, São Paulo, SP 05508-000, Brazil. Electronic address: gbiude@usp.br., Souza Junior AC; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil. Electronic address: adriano.junior.110@ufrn.edu.br., Pereira Batista LDS; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil. Electronic address: leonam.batista.125@ufrn.edu.br., Rogero MM; Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo, 715 - Cerqueira César, São Paulo, SP 01246-904, Brazil; Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers São Paulo Research Foundation, Laboratory of Food Engineering, Semi Industrial Ed. - R. do Lago, 250 - Bloco C, São Paulo, SP 05468-140, Brazil. Electronic address: mmrogero@usp.br., Barbosa F Jr; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/nº - Vila Monte Alegre, Ribeirão Preto, SP 14040903, Brazil. Electronic address: fbarbosa@fcfrp.usp.br., Cozzolino SMF; Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 14 - Butantã, São Paulo, SP 05508-000, Brazil. Electronic address: smfcozzo@usp.br., Dantas-Komatsu RCS; Postgraduate Program in Pharmaceutical Sciences, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Rua General Gustavo Cordeiro de Faria, s/nº - Petrópolis, Natal, RN 59012-570, Brazil. Electronic address: raquel.komatsu.068@ufrn.edu.br., Marinho Costa KZS; Brazilian Company of Hospital Services (EBSERH), Onofre Lopes University Hospital, Av. Nilo Peçanha, 620 - Petrópolis, Natal, RN 59012-300, Brazil. Electronic address: karina.marinho@ufrn.br., Reis BZ; Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000. University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil; Department of Nutrition, Federal University of Rio Grande do Norte, Rio Grande do Norte, Avenida Senador Salgado Filho, 3000, University Campus - Lagoa Nova, Natal, RN 59078-970, Brazil. Electronic address: bruna.zavarize@ufrn.br.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2024 Jul 20; Vol. 86, pp. 127499. Date of Electronic Publication: 2024 Jul 20.
DOI: 10.1016/j.jtemb.2024.127499
Abstrakt: Introduction: Chronic low-grade inflammation and oxidative stress are pivotal contributors to the metabolic complications associated with obesity. Selenoprotein P (SELENOP) and glutathione peroxidase 1 (GPx1) are selenoproteins involved in the reduction of reactive oxygen species and pro-inflammatory cytokines levels. Nutritional epigenomics revealed the interaction of microRNAs and nutrients with an important impact on metabolic pathways involved in obesity. However, the knowledge regarding the influence of microRNA on selenium biomarkers and its impact on metabolic pathways related to obesity remains scarce. Thus, the aim of this study was to investigate the association of plasma miR-7-5p expression with selenium and inflammatory biomarkers in women with overweight/obesity.
Material and Methods: Anthropometric evaluations were performed and blood samples were collected for the analysis of fasting glucose, insulin, inflammatory and selenium biomarkers, and miR-7-5p expression in 54 women with overweight/obesity. Gene expression of SELENOP and GPX1 were evaluated in peripheral mononuclear blood cells.
Results: This study observed a negative correlation between SELENOP levels and miR-7-5p (rho = -0.350; p = 0.018). Additionally, it was observed that body fat (OR = 0.737; p = 0.011), age (OR = 1.214; p = 0.007), and miR-7-5p (OR = 0.990; p = 0.015) emerged as significant predictors of SELENOP levels.
Conclusions: In conclusion, we observed a significant inverse association between miR-7-5p expression and SELENOP concentration in overweight/obese women, suggesting that age and percentage of body fat are also associated.
Trial Registration Number: Brazilian Registry of Clinical Trials (ReBEC) number RBR-2nfy5q.
Competing Interests: Declaration of Competing Interest The authors of this manuscript declare that there are no conflicts of interest.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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