Immunohistochemical ERG positivity is associated with decreased PSMA expression and lower visibility in corresponding [ 68 Ga]Ga-PSMA-11 PET scans of primary prostate cancer.

Autor: Rupp NJ; Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zürich, Switzerland. niels.rupp@usz.ch.; University of Zurich, Zurich, Switzerland. niels.rupp@usz.ch., Freiberger SN; Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zürich, Switzerland.; University of Zurich, Zurich, Switzerland., Ferraro DA; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil., Laudicella R; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy., Heimer J; Seminar for Statistics, Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland., Muehlematter UJ; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Poyet C; Department of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Moch H; Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zürich, Switzerland.; University of Zurich, Zurich, Switzerland., Eberli D; University of Zurich, Zurich, Switzerland.; Department of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Rüschoff JH; Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zürich, Switzerland., Burger IA; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Nuclear Medicine, Cantonal Hospital Baden, affiliated Hospital for Research and Teaching of the Faculty of Medicine of the University of Zurich, Baden, Switzerland.
Jazyk: angličtina
Zdroj: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Jul 31. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1007/s00259-024-06856-x
Abstrakt: Purpose: TMPRSS2:ERG gene fusion negatively regulates PSMA expression in prostate adenocarcinoma (PCa) cell lines. Therefore, immunohistochemical (IHC) ERG expression, a surrogate for an underlying ERG rearrangement, and PSMA expression patterns in radical prostatectomy (RPE) specimens of primary PCa, including corresponding PSMA-PET scans were investigated.
Methods: Two cohorts of RPE samples (total n=148): In cohort #1 (n=62 patients) with available RPE and preoperative [ 68 Ga]Ga-PSMA-11 PET, WHO/ISUP grade groups, IHC-ERG (positive vs. negative) and IHC-PSMA expression (% PSMA-negative tumour area, PSMA %neg ) were correlated with the corresponding SUV max . In the second cohort #2 (n=86 patients) including RPE only, same histopathological parameters were evaluated.
Results: Cohort #1: PCa with IHC-ERG expression (35.5%) showed significantly lower IHC-PSMA expression and lower SUV max values on the corresponding PET scans. Eight of 9 PCa with negative PSMA-PET scans had IHC-ERG positivity, and confirmed TMPRSS2::ERG rearrangement. In IHC-PSMA positive PCa, IHC-ERG positivity was significantly associated with lower SUV max values. In cohort #2, findings of higher IHC-PSMA %neg and IHC-ERG expression was confirmed with only 0-10% PSMA %neg tumour areas in IHC-ERG-negative PCa.
Conclusion: IHC-ERG expression is significantly associated with more heterogeneous and lower IHC-PSMA tissue expression in two independent RPE cohorts. There is a strong association of ERG positivity in RPE tissue with lower [ 68 Ga]Ga-PSMA-11 uptake on corresponding PET scans. Results may serve as a base for future biomarker development to enable tumour-tailored, individualized imaging approaches.
(© 2024. The Author(s).)
Databáze: MEDLINE
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