The influence of sex on heart failure mortality.

Autor: Colombo D; Division of Cardiology - Fondazione IRCCS Policlinico S Matteo, Pavia., Mercurio V; Department of Translational Medical Sciences, 'Federico II' University, Naples., Klersy C; Biostatistics and Clinical Trial Center - Fondazione IRCCS Policlinico S Matteo., Temporelli P; Istituti Clinici Scientifici Maugeri, IRCCS, Department of Cardiology, Istituto Scientifico di Veruno, Novara., Rossi A; Ospedale Magalini, Villafranca, Verona., Carluccio E; Cardiology and Cardiovascular Pathophysiology, S. Maria della Misericordia Hospital, University of Perugia, Perugia., La Rovere MT; Istituti Clinici Scientifici Maugeri, IRCCS, Department of Cardiology, Istituto Scientifico di Montescano, Pavia., Dini FLL; Istituto Auxologico, IRCCS, Milano., Nappi R; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, Pavia, Italy., Acquaro M; Division of Cardiology - Fondazione IRCCS Policlinico S Matteo, Pavia., Greco A; Division of Cardiology - Fondazione IRCCS Policlinico S Matteo, Pavia., Turco A; Division of Cardiology - Fondazione IRCCS Policlinico S Matteo, Pavia., Schirinzi S; Division of Cardiology - Fondazione IRCCS Policlinico S Matteo, Pavia., Scelsi L; Division of Cardiology - Fondazione IRCCS Policlinico S Matteo, Pavia., Ghio S; Division of Cardiology - Fondazione IRCCS Policlinico S Matteo, Pavia.
Jazyk: angličtina
Zdroj: Journal of cardiovascular medicine (Hagerstown, Md.) [J Cardiovasc Med (Hagerstown)] 2024 Sep 01; Vol. 25 (9), pp. 693-699. Date of Electronic Publication: 2024 Jul 22.
DOI: 10.2459/JCM.0000000000001656
Abstrakt: Aims: Little research has investigated how sex may affect the prognosis of patients with chronic heart failure (HF). The present study was aimed at exploring sex-specific differences in prognosis in a cohort of patients with chronic HF, categorized according to severity of left ventricular dysfunction (HFrEF, HFmrEF and HFpEF), right ventricular (RV) dysfunction and ischemic (IHD) or nonischemic (no-IHD) etiology.
Methods: This retrospective analysis included 1640 HF patients of whom 24% were females, 759 patients had IHD, 1110 patients had HFrEF, 147 patients had HFmrEF and 383 patients had HFpEF. The median follow-up period was 63 months (25th-75th 27-93).
Results: In the no-IHD group, no statistically significant sex differences emerged regarding survival, regardless of age and severity of cardiac dysfunction. In contrast, in the IHD group, females had a significantly lower event rate than males in the age group between 65 and 79 years [hazard ratio (HR) 0.39; 95% confidence interval (CI): 0.86-0.18; P  < 0.01]; in addition, a lower event rate was observed in females compared with males among patients with HFrEF (HR 0.47; 95% CI: 0.88-0.25; P  < 0.01), among patients without RV dysfunction (HR 0.58; 95% CI: 1.02-0.33; P  = 0.048) and among patients without diabetes (HR 0.44; 95% CI: 0.84-0.23; P  < 0.01).
Conclusion: In nonischemic patients there was no difference between males and females in terms of survival whereas in patients with ischemic etiology survival was better in females among elderly patients, in HFrEF patients, in the absence of RV dysfunction and in the absence of diabetes.
(Copyright © 2024 Italian Federation of Cardiology - I.F.C. All rights reserved.)
Databáze: MEDLINE
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