Development of PHBV electrospun fibers containing a borate bioactive glass doped with Co, Cu, and Zn for wound dressings.

Autor: Dos Santos VR; Institute of Science and Technology, Bioceramics Laboratory, Federal University of São Paulo, São José dos Campos, São Paulo, Brazil., Campos TMB; Department of Prosthodontics and Periodontology, University of São Paulo, Bauru School of Dentistry, Bauru, São Paulo, Brazil., Anselmi C; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.; Department of Morphology and Pediatric Dentistry, School of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., de Souza JR; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.; Institute of Science and Technology, Department of Dental Materials and Prosthodontics, São Paulo State University, São Paulo, Brazil., Lemes AP; Institute of Science and Technology, Polymers and Biopolymers Technology Laboratory, Federal University of São Paulo, São José dos Campos, São Paulo, Brazil., Thim GP; Laboratory of Plasma and Processes (LPP), Technological Institute of Aeronautics (ITA), São José dos Campos, São Paulo, Brazil., Bottino MC; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA., Borges ALS; Institute of Science and Technology, Department of Dental Materials and Prosthodontics, São Paulo State University, São Paulo, Brazil., de Sousa Trichês E; Institute of Science and Technology, Bioceramics Laboratory, Federal University of São Paulo, São José dos Campos, São Paulo, Brazil.; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2024 Aug; Vol. 112 (8), pp. e35459.
DOI: 10.1002/jbm.b.35459
Abstrakt: Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers embedded with borate glasses of 45B5 composition doped with Co 2+ , Cu 2+ , and Zn 2 + (46.1 B₂O₃26.9-X CaO24.4 Na₂O2.6 P₂O₅, X CoO/CuO/ZnO mol % (X = 0-5)) were produced by electrospinning for wound healing applications. Prior to their addition, the glasses exhibited two broad halos typical of a vitreous borate network, which were mainly composed of ring-type metaborate structural units. The particle distribution in the PHBV nanofibers embedded with 45B5 borate bioactive glasses is present in isolated and agglomerated states, being partially coated by a polymeric layer-except for the cobalt-doped glass, which resulted in a successful encapsulation with 100% embedding efficiency. The incorporation of the glasses reduced the PHBV crystallinity degree and its decomposition temperature, as well as its mechanical properties, including Young's modulus, tensile strength, and elongation at break. The neat PHBV fibers and those containing the cobalt-doped glasses demonstrated great cytocompatibility with human keratinocytes (HaCat), as suggested by the high cell viability after 7 days of exposure. Further studies are needed to fully understand the wound healing potential of these fibers, but our results significantly contribute to the area.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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