Löfgren syndrome, characteristics of Japanese cases: a case and a review of the literature.

Autor:	Taguchi H; Department of Rheumatology, Kobe City Medical Center General Hospital, Hyogo, Japan., Sumitomo S; Department of Rheumatology, Kobe City Medical Center General Hospital, Hyogo, Japan., Oka H; Department of Rheumatology, Kobe City Medical Center General Hospital, Hyogo, Japan., Hara S; Department of Diagnostic Pathology, Kobe City Medical Center General Hospital, Hyogo, Japan., Ohmura K; Department of Rheumatology, Kobe City Medical Center General Hospital, Hyogo, Japan.
Jazyk:	angličtina
Zdroj:	Modern rheumatology case reports [Mod Rheumatol Case Rep] 2024 Jul 31. Date of Electronic Publication: 2024 Jul 31.
DOI:	10.1093/mrcr/rxae034
Abstrakt:	Löfgren syndrome (LS) is a sarcoidosis subtype characterized by an acute disease course, bilateral hilar lymphadenopathy, erythema nodosum, and ankle arthritis. LS in Caucasians appears to be self-limiting; however, our patients required glucocorticoid (GC) treatment. Here, we present a case of LS and review the literature to identify the characteristics of the Japanese patients with LS. Sixty-six-year-old woman was referred to our hospital; she initially presented with an acute onset of low-grade fever and ankle arthritis, followed by erythema nodosum. Skin biopsy revealed a non-caseating granuloma, and chest computed tomography scan displayed bilateral hilar lymphadenopathy; she was diagnosed with LS. Her arthralgia ameliorated spontaneously, but erythema persisted, necessitating GC treatment. Literature review revealed that the Japanese LS patients showed more fever, were more frequently treated with GC and more patients seemed to relapse, which may be explained by the absence of human leukocyte antigen-DR isotype 3, a good prognostic allele in Caucasians. Japanese LS may cause severe symptoms after development because of the differences in human leukocyte antigen from foreign countries. For early diagnosis, it is important to evaluate erythema nodosum and bilateral hilar lymphadenopathy in patients with polyarthritis involving ankle arthralgia. (© Japan College of Rheumatology 2024. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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