Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life.

Autor: Montante S; BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1G1, BC, Canada., Ben-Othman R; Telethon Kids Institute Perth Children's Hospital, 15 Hospital Avenue, Nedlands 6009, WA, Australia.; RAN BioLinks Ltd., 10212 Yonge Street, 202, Richmond Hill L4C 3B6, Ontario, Canada., Amenyogbe N; Telethon Kids Institute Perth Children's Hospital, 15 Hospital Avenue, Nedlands 6009, WA, Australia.; Department of Microbiology and Immunology Department of Pediatrics; Dalhousie University, 6299 South Street, Halifax B3H 4R2, Canada., Angelidou A; Precision Vaccines Program Department of Pediatrics Boston Children's Hospital, Boston, MA, USA.; Department of Neonatology Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA, USA., van den Biggelaar A; Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute University of Western Australia Perth, 15 Hospital Avenue, Nedlands, WA 6009, Australia., Cai B; Department of Pediatrics BC Children's Hospital University of British Columbia, 4480 Oak Street, Vancouver V6H 3V4, BC, Canada., Chen Y; BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1G1, BC, Canada., Darboe A; Vaccines and Immunity Theme Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Banjul P.O. Box 273, Gambia., Diray-Arce J; Precision Vaccines Program Department of Pediatrics Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Ford R; Papua New Guinea Institute of Medical Research, Homate Street, 441, Goroka, Eastern Highlands Province, Papua New Guinea., Idoko O; Department of Clinical Research Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Lee A; Department of Molecular Biology and Biochemistry Simon Fraser University, 8888 University Dr. Burnaby V5A1S6, Burnaby, British Columbia, Canada., Lo M; Telethon Kids Institute Perth Children's Hospital, 15 Hospital Avenue, Nedlands 6009, WA, Australia., McEnaney K; Precision Vaccines Program Department of Pediatrics Boston Children's Hospital, Boston, MA, USA., Malek M; BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1G1, BC, Canada., Martino D; Wal-yan Respiratory Research Centre Telethon Kids Institute University of Western Australia, Perth, Australia., Masiria G; Papua New Guinea Institute of Medical Research, Homate Street, 441, Goroka, Eastern Highlands Province, Papua New Guinea., Odumade OA; Precision Vaccines Program Department of Pediatrics Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pomat W; Papua New Guinea Institute of Medical Research, Homate Street, 441, Goroka, Eastern Highlands Province, Papua New Guinea., Shannon C; PROOF Centre of Excellence, 10th floor, 1190 Hornby Street, Vancouver V6Z 2K5, British Columbia, Canada.; UBC Centre for Heart Lung Innovation St. Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada., Smolen K; Precision Vaccines Program Department of Pediatrics Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Consortium TE; NIH, National Institute of Health, Bethesda, USA., Ozonoff A; Precision Vaccines Program Department of Pediatrics Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Richmond P; Telethon Kids Institute Perth Children's Hospital, 15 Hospital Avenue, Nedlands 6009, WA, Australia.; Division of Pediatrics School of Medicine University of Western Australia, 35 Stirling Highway, Crawley 6009, WA, Australia., Tebbutt S; PROOF Centre of Excellence, 10th floor, 1190 Hornby Street, Vancouver V6Z 2K5, British Columbia, Canada.; UBC Centre for Heart Lung Innovation St. Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada., Levy O; Precision Vaccines Program Department of Pediatrics Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kampmann B; Vaccines and Immunity Theme Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Banjul P.O. Box 273, Gambia.; Centre for Global Health and Institute for International Health Charite Universitatsmedizin, Berlin, Germany., Brinkman R; BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1G1, BC, Canada.; Department of Medical Genetics University of British Columbia, 675 West 10th Avenue, Vancouver, British Columbia V6T1Z4, Canada., Kollmann T; Telethon Kids Institute Perth Children's Hospital, 15 Hospital Avenue, Nedlands 6009, WA, Australia.; Department of Pediatrics BC Children's Hospital University of British Columbia, 4480 Oak Street, Vancouver V6H 3V4, BC, Canada.; Microbiology and Immunology Pediatric Infectious Diseases Dalhousie University, CEO, Born, Strong Initiative, Halifax, Nova Scotia, Canada.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2024 Jul 23; Vol. 2024, pp. 1117796. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).
DOI: 10.1155/2024/1117796
Abstrakt: The first few days of life are characterized by rapid external and internal changes that require substantial immune system adaptations. Despite growing evidence of the impact of this period on lifelong immune health, this period remains largely uncharted. To identify factors that may impact the trajectory of immune development, we conducted stringently standardized, high-throughput phenotyping of peripheral white blood cell (WBC) populations from 796 newborns across two distinct cohorts (The Gambia, West Africa; Papua New Guinea, Melanesia) in the framework of a Human Immunology Project Consortium (HIPC) study. Samples were collected twice from each newborn during the first week of life, first at Day of Life 0 (at birth) and then subsequently at Day of Life 1, 3, or 7 depending on the randomization group the newborn belongs to. The subsequent analysis was conducted at an unprecedented level of detail using flow cytometry and an unbiased automated gating algorithm. The results showed that WBC composition in peripheral blood changes along patterns highly conserved across populations and environments. Changes across days of life were most pronounced in the innate myeloid compartment. Breastfeeding, and at a smaller scale neonatal vaccination, were associated with changes in peripheral blood neutrophil and monocyte cell counts. Our results suggest a common trajectory of immune development in newborns and possible association with timing of breastfeeding initiation, which may contribute to immune-mediated protection from infection in early life. These data begin to outline a specific window of opportunity for interventions that could deliberately direct WBC composition, and with that, immune trajectory and thus ontogeny in early life. This trial is registered with NCT03246230.
Competing Interests: Ofer Lefy declared the competing interest, he is a named inventor on patents held by Boston Children's Hospital relating to vaccine adjuvants (e.g., EP3709998A1) and human in vitro systems that model responses to immunomodulators and vaccines (e.g., US20150152385A1). He is an advisor to GlaxoSmithKline (GSK) and Hillevax and a cofounder of Ovax, Inc. The other authors declared no competing interest.
(Copyright © 2024 Sebastiano Montante et al.)
Databáze: MEDLINE
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