Impact of Helicobacter pylori Eradication on Surgical Treatment of Peptic Ulcer Disease: Systematic Review.

Autor:	Aljuhani SA; General Surgery, Al Thager Hospital, Jeddah, SAU., Sherwani AA; General Surgery, King Fahad Central Hospital, Jazan, SAU., Alnamshah FO; Internal Medicine, Rijal Alma Hospital, Abha, SAU., Alaeq RA; Medical Laboratories Technology, Faculty of Applied Medical Sciences, Taibah University, Medina, SAU., Alrahma HA; Gastroentrology and Hepatology, Salmaniya Medical Complex, Manama, BHR., Jarad MM; General Surgery, King Fahad Central Hospital, Jazan, SAU., Hakami AA; General Surgery, King Fahad Central Hospital, Jazan, SAU., Mobarki TH; General Surgery, King Fahad Central Hospital, Jazan, SAU., Al-Khairat HK; General Surgery, Health Affairs in Jazan Region, Jazan, SAU., Sahal YA; General Surgery, Ministry of Health, Jazan, SAU., Bakhsh AW; General Surgery, Al Thager Hospital, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 30; Vol. 16 (6), pp. e63523. Date of Electronic Publication: 2024 Jun 30 (Print Publication: 2024).
DOI:	10.7759/cureus.63523
Abstrakt:	Peptic ulcer disease (PUD) poses a significant global healthcare challenge, with an intricate interplay between stomach acid-pepsin levels and mucosal protective mechanisms. The emergence of Helicobacter pylori (H. pylori) as a major etiological factor revolutionized the therapeutic landscape, highlighting the importance of bacterial eradication in PUD management. Surgical intervention remains vital, particularly in cases of perforated peptic ulcers, despite a shift towards conservative approaches. Understanding the impact of H. pylori eradication on surgical outcomes is crucial for optimizing PUD management. This systematic review was conducted to assess how H. pylori eradication treatment impacts surgical results in patients with PUD. The criteria for inclusion involved research studies on individuals aged 18 years and older with a diagnosis of PUD that necessitated surgical treatment. Important results comprised eradication rates, complications after surgery, recurrence rates, and overall outcomes for patients. Two researchers independently screened and extracted data from electronic databases using a thorough search strategy. The evaluation of quality employed standardized instruments for randomized controlled trials and cohort studies. Nine research projects met the requirements for inclusion, offering information on the effectiveness of H. pylori elimination treatment on surgical results. Different rates of eradication were noted, with a notable number of patients experiencing postoperative complications. Recurrence of ulcers was a concern, despite treatment, emphasizing the complexity of PUD management. Studies have shown that eradication therapy is effective in certain patient groups, like young men with perforated peptic ulcers. Still, there are obstacles, especially for patients who test negative for H. pylori and experience recurring ulcers. The integration of H. pylori eradication with surgical intervention represents a holistic approach to PUD management. Although eradication therapy has the potential to enhance surgical results, difficulties remain, requiring personalized treatment approaches that consider patients' unique characteristics and the cause of the disease. This research adds to the growing knowledge of PUD treatment, stressing the importance of proper management. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Aljuhani et al.)
Databáze:	MEDLINE
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