Anterior-Segment Optical Coherence Tomography-Based Evaluation of the Journey of a Bleb in the Early Postoperative Period.

Autor:	Choudhary TS; Glaucoma and Squint Clinic, Shri Chimanlal Harilal (CH) Nagri Municipal Eye Hospital, Ahmedabad, IND., Raval RM; Glaucoma and Squint Clinic, Shri Chimanlal Harilal (CH) Nagri Municipal Eye Hospital, Ahmedabad, IND., Shah KS; Glaucoma and Squint Clinic, Shri Chimanlal Harilal (CH) Nagri Municipal Eye Hospital, Ahmedabad, IND., Gajwani SM; Glaucoma and Squint Clinic, Shri Chimanlal Harilal (CH) Nagri Municipal Eye Hospital, Ahmedabad, IND., Mehta RJ; Department of Psychiatry, Gujarat Medical Education and Research Society (GMERS) Medical College and Hospital, Navsari, IND., Patel MC; Department of Pedodontics and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 30; Vol. 16 (6), pp. e63512. Date of Electronic Publication: 2024 Jun 30 (Print Publication: 2024).
DOI:	10.7759/cureus.63512
Abstrakt:	Introduction In the early postoperative period following trabeculectomy, monitoring the journey of bleb formation is crucial for assessing surgical success. Anterior-segment optical coherence tomography (AS-OCT) emerges as a powerful tool in this pursuit, offering high-resolution imaging of bleb morphology and dynamics. This study aims to evaluate the internal structure of blebs through their maturation phases using AS-OCT. Methods Fifty-five eyes undergoing trabeculectomy were enrolled in a prospective observational study. Serial AS-OCT examinations were done on day 1, week 1, week 3, and week 6 postoperatively; bleb parameters were calculated and correlated with intraocular pressure (IOP). Results IOP control was seen in 45 eyes six months of post-trabeculectomy. Multiform bleb wall reflectivity (BWR) statistically correlates with the success of trabeculectomy. Blebs were successful if BWR showed no change from day 1 to week 6. BWR remained the same on all follow-ups if week 1 bleb wall thickness (BWT) was less than 129.5 microns with 82.6% sensitivity and 83.3% specificity. The cumulative hazard of change in BWR is estimated to be approximately 5.6%, 15.7%, and 17.9% at week 1, week 3, and week 6 follow-ups, respectively. Conclusions Successful blebs showed consistent BWR from day 1 to week 6 of follow-up. Serial AS-OCT examination for changes in BWR in early stages can be done to predict the fate of bleb. The maximum change in BWR occurs between the week 1 and week 3 follow-up periods requiring close follow-up. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Review Board, Smt. Nathiba Hargovandas Lakhmichand (NHL) Municipal Medical College, Ahmedabad issued approval NHLIRB/2022/DECEMBER/8/NO.1. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Choudhary et al.)
Databáze:	MEDLINE
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