Case-control study on post-COVID-19 conditions reveals severe acute infection and chronic pulmonary disease as potential risk factors.

Autor:	Ghosh P; nference Labs, Bengaluru, India., Niesen MJM; nference, Inc., Cambridge, MA 02139, USA., Pawlowski C; nference, Inc., Cambridge, MA 02139, USA., Bandi H; nference, Inc., Cambridge, MA 02139, USA., Yoo U; nference, Inc., Cambridge, MA 02139, USA., Lenehan PJ; nference, Inc., Cambridge, MA 02139, USA., Kumar-M P; nference Labs, Bengaluru, India., Nadig M; nference, Inc., Cambridge, MA 02139, USA., Ross J; nference, Inc., 18 3rd St. S.W., Rochester, MN 55902, USA., Ardhanari S; nference, Inc., 2424 Erwin Road, Durham, NC 27705, USA., O'Horo JC; Mayo Clinic, Rochester, MN, USA., Venkatakrishnan AJ; nference, Inc., Cambridge, MA 02139, USA., Rosen CJ; Maine Medical Center, Portland, ME 04102, USA.; RECOVER Maine, MaineHealth Institute for Research, Scarborough, ME, USA., Telenti A; Vir Biotechnology, Inc., San Francisco, CA, USA., Hurt RT; Mayo Clinic, Rochester, MN, USA., Soundararajan V; nference Labs, Bengaluru, India.; nference, Inc., Cambridge, MA 02139, USA.; nference, Inc., 18 3rd St. S.W., Rochester, MN 55902, USA.; nference, Inc., 2424 Erwin Road, Durham, NC 27705, USA.; Anumana, Inc., Cambridge, MA 02139, USA.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jun 28; Vol. 27 (8), pp. 110406. Date of Electronic Publication: 2024 Jun 28 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110406
Abstrakt:	Post-COVID-19 conditions (long COVID) has impacted many individuals, yet risk factors for this condition are poorly understood. This retrospective analysis of 88,943 COVID-19 patients at a multi-state US health system compares phenotypes, laboratory tests, medication orders, and outcomes for 1,086 long-COVID patients and their matched controls. We found that history of chronic pulmonary disease (CPD) (odds ratio: 1.9, 95% CI: [1.5, 2.6]), migraine (OR: 2.2, [1.6, 3.1]), and fibromyalgia (OR: 2.3, [1.3, 3.8]) were more common for long-COVID patients. During the acute infection phase long COVID patients exhibited high triglycerides, low HDL cholesterol, and a high neutrophil-lymphocyte ratio; and were more likely hospitalized (5% vs. 1%). Our findings suggest severity of acute infection and history of CPD, migraine, chronic fatigue syndrome (CFS), or fibromyalgia as risk factors for long COVID. These results suggest that suppressing acute disease severity proactively, especially in patients at high risk, can reduce incidence of long COVID. Competing Interests: P.G. was an employee of nference and is a current employee of ConcertAI and has financial interests in these companies and the successful application of this research. M.N., C.P., H.B., U.Y., P.L., P.K., M.N., J.R., S.A., and A.V. are employees of nference and have financial interests in the company and in the successful application of this research. V.S. is an employee of nference and Anumana and has financial interests in these companies and in the successful application of this research. J.O. has received small grants from nference, Inc., and personal consulting fees from Bates College and Elsevier Inc. All of these activities are outside of the present work. R.H. has received a small grant from nference, Inc. and Zealand Pharmaceuticals, and consulting fees from Nestle Nutrition. C.R. acknowledges funding from the National Institutes of Health (1OT2HL162096-01). A.T. is an employee and shareholder of Vir Biotechnology Inc. (© 2024 The Author(s).)
Databáze:	MEDLINE
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