| Autor: |
Li ZM; Wadsworth Center, New York State Department of Health, Albany, New York 12237, United States., Kannan K; Wadsworth Center, New York State Department of Health, Albany, New York 12237, United States.; Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, New York 12237, United States. |
| Jazyk: |
angličtina |
| Zdroj: |
Environmental science & technology [Environ Sci Technol] 2024 Aug 13; Vol. 58 (32), pp. 14169-14179. Date of Electronic Publication: 2024 Jul 30. |
| DOI: |
10.1021/acs.est.4c05991 |
| Abstrakt: |
Laboratory animal studies have reported the biliary excretion of chemicals following exposure. Nevertheless, feces are rarely used as a matrix in biomonitoring of chemical exposures. In this study, feces and urine from pet dogs and cats were analyzed for the presence of 45 plasticizers, 45 environmental phenols, and 31 pesticides. Thirty-two analytes were detected in ≥70% pet feces, while up to 29 analytes were frequently (≥70%) found in urine. The sum concentrations of all analytes (∑All) in pet feces were significantly higher than those measured in urine (median: 393-666 ng/g wet weight in feces vs 216-464 ng/mL in urine). Plasticizers were the dominant class of chemicals, accounting for 81-97% and 69-77% of ∑All in urine and feces, respectively. Analyte concentrations measured in paired urine and feces exhibited weak correlations. The excretion rates of the chemicals via urine and feces were calculated through a reverse dosimetry approach. Low-molecular-weight phthalates excreted predominantly in urine, whereas high-molecular-weight phthalates and several organophosphate triesters were excreted predominantly in feces. The fecal excretion rates of parabens, benzophenones, bisphenols, naphthalene, 2,4-dichloronicotinic acid, and 4-nitrophenol were similar to or higher than those of urinary excretion. Our results suggest that feces are an important matrix in biomonitoring of exposure to environmental chemicals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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