Interconnected microbiomes-insights and innovations in female urogenital health.

Autor: Al KF; Department of Microbiology and Immunology, The University of Western Ontario, London, Canada.; Lawson Health Research Institute, St. Joseph's Hospital, London, Canada., Parris J; Kimberly Clark Corporation, Global Research & Engineering, Roswell, GA, USA., Engelbrecht K; Kimberly Clark Corporation, Global Research & Engineering, Neenah, WI, USA., Reid G; Department of Microbiology and Immunology, The University of Western Ontario, London, Canada.; Lawson Health Research Institute, St. Joseph's Hospital, London, Canada.; Division of Urology, Department of Surgery, The University of Western Ontario, London, Canada., Burton JP; Department of Microbiology and Immunology, The University of Western Ontario, London, Canada.; Lawson Health Research Institute, St. Joseph's Hospital, London, Canada.; Division of Urology, Department of Surgery, The University of Western Ontario, London, Canada.
Jazyk: angličtina
Zdroj: The FEBS journal [FEBS J] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30.
DOI: 10.1111/febs.17235
Abstrakt: The paradigm that the vaginal microbiota is a protective gateway for the urinary and reproductive systems has endured for more than a century and driven decades of probiotic research. Evidence robustly supports the notion that healthy urogenital microbiomes are predominantly colonized by lactobacilli, particularly Lactobacillus crispatus, which can acidify the local environment and protect against urogynecologic pathogen colonization. However, recent studies are beginning to delve deeper into the intricate mechanistic interactions connecting the microbiome, its diverse functional potential, host immunity, pathogens, and the development of urogenital diseases. Leveraging these emerging insights alongside past successes presents promising opportunities for future therapies aimed at enhancing the management of conditions such as bacterial vaginosis, urinary tract infections, bladder pain, urinary incontinence, and beyond.
(© 2024 Federation of European Biochemical Societies.)
Databáze: MEDLINE
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