Highly homologous simian T-cell leukemia virus type 1 genome in Japanese macaques: a large cohort study.

Autor: Hiraga K; Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan.; Management Department of Biosafety, Laboratory Animal, and Pathogen Bank, National Institute of Infectious Diseases, Tokyo, Japan., Kitamura T; Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan.; National Institute of Animal Health, National Agriculture and Food Research Organization, Tokyo, Japan., Kuramitsu M; Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan. mkura@niid.go.jp., Murata M; Center for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, Japan., Tezuka K; Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan., Okuma K; Department of Microbiology, Faculty of Medicine, Kansai Medical University, Osaka, Japan., Hamaguchi I; Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan.; Department of Clinical Laboratory, Subaru Health Insurance Society Ota Memorial Hospital, Gunma, Japan., Akari H; Center for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Aichi, Japan. akari.hirofumi.5z@kyoto-u.ac.jp., Mizukami T; Research Center for Biological Products in the Next Generation, National Institute of Infectious Diseases, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Virology journal [Virol J] 2024 Jul 30; Vol. 21 (1), pp. 166. Date of Electronic Publication: 2024 Jul 30.
DOI: 10.1186/s12985-024-02434-7
Abstrakt: Background: Simian T-cell leukemia virus type 1 (STLV-1) is a retrovirus closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia (ATL). It has been shown that Japanese macaques (Macaca fuscata, JMs) are one of the main hosts of STLV-1 and that a high percentage of JMs (up to 60%) are infected with STLV-1; however, the molecular epidemiology of STLV-1 in JMs has not been examined.
Methods: In this study, we analyzed full-length STLV-1 genome sequences obtained from 5 independent troops including a total of 68 JMs.
Results: The overall nucleotide heterogeneity was 4.7%, and the heterogeneity among the troops was 2.1%, irrespective of the formation of distinct subclusters in each troop. Moreover, the heterogeneity within each troop was extremely low (>99% genome homology) compared with cases of STLV-1 in African non-human primates as well as humans. It was previously reported that frequent G-to-A single-nucleotide variants (SNVs) occur in HTLV-1 proviral genomes in both ATL patients and HTLV-1 carriers, and that a G-to-A hypermutation is associated with the cellular antiviral restriction factor, Apobec3G. Surprisingly, these SNVs were scarcely observed in the STLV-1 genomes in JMs.
Conclusions: Taken together, these results indicate that STLV-1 genomes in JMs are highly homologous, at least in part due to the lack of Apobec3G-dependent G-to-A hypermutation.
(© 2024. The Author(s).)
Databáze: MEDLINE
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