Incorporating the perspectives of participants and research coordinators on home spirometry into clinical trial design: The example of the OUTREACH study.

Autor: M R; Center for Respiratory Biology and Therapeutics, Seattle Children's Research Institute, United States; Department of Pediatrics, University of Washington School of Medicine, United States. Electronic address: margaret.rosenfeld@seattlechildrens.org., A B; University of Arkansas for Medical Sciences, United States., G S; Boston Children's Hospital, United States., E NK; Seattle Children's Hospital, United States., B F; Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, United States., B ZC; Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle Children's Research Institute, United States., Al H; Biomedical Informatics and Medical Education, University of Washington School of Medicine, United States.
Jazyk: angličtina
Zdroj: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2024 Jul; Vol. 23 (4), pp. 739-743. Date of Electronic Publication: 2024 Jul 29.
DOI: 10.1016/j.jcf.2024.06.014
Abstrakt: Background: We undertook a human-centered design approach to design the OUTREACH study of home spirometry as a CF clinical trial endpoint. We conducted a qualitative needs assessment to elicit the perspectives of people with CF (PwCF) and research coordinators (RCs) about home spirometry in the research setting and co-produced written and video home spirometry instructions in partnership with representatives from these stakeholder groups.
Methods: We conducted 7 focus groups of PwCF (N = 27), caregivers of children with CF (N = 6), or RCs (N = 24) to elicit current experiences, barriers and facilitators of home spirometry across 6 target areas, followed by discussion and prioritization. The co-production team, composed of 3 PwCF, 3 RCs and study team members created written and video training materials.
Results: While most PwCF and caregivers found home spirometry convenient, many experienced technical barriers, reported a "learning curve", and expressed uncertainty about the quality and reliability of measurements. Major barriers identified by RCs included tailoring participant training to individual needs, scheduling remote coaching, and performing effective coaching remotely. Participants offered age-specific recommendations in key domains: training materials and procedures, remote coaching, monitoring progress and maintaining engagement. Co-produced training materials included handouts and videos on how to perform spirometry, and troubleshooting, cleaning, and maintaining home spirometers.
Conclusions: The OUTREACH design was improved by incorporating results of the needs assessment. The home spirometry training materials are freely available for public use. We hope our results and materials can help to inform the design and success of remote clinical trials of the future.
Competing Interests: Declaration of competing interest All authors declare that they have no conflict of interest
(Copyright © 2024 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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