Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights.

Autor: Khan ZAW; Department of Gastroenterology and Hepatology, Ambulatory Care Center, Hamad Medical Corporation, Doha 3050, Qatar. Electronic address: Drzohaibkhan100@gmail.com., Ab Ib Swehli H; Department of Medicine, Ascension Saint Francis Hospital, Evanston, IL, 60202, USA., Hani Al-Battah A; Department of Gastroenterology and Hepatology, Ambulatory Care Center, Hamad Medical Corporation, Doha 3050, Qatar., Mahmoud M; Department of Medicine, Southwest Health Campus, Bunbury Hospital, WA, 6230, Australia., John A; Department of Gastroenterology and Hepatology, Ambulatory Care Center, Hamad Medical Corporation, Doha 3050, Qatar., Al-Ejji K; Department of Gastroenterology and Hepatology, Ambulatory Care Center, Hamad Medical Corporation, Doha 3050, Qatar., Al Kaabi S; Department of Gastroenterology and Hepatology, Ambulatory Care Center, Hamad Medical Corporation, Doha 3050, Qatar., Varughese B; Department of Gastroenterology and Department of Medicine, Hamad Medical Corporation, Doha 3050, Qatar., Singh R; Medical Research Center, Hamad Medical Corporation, Doha 3050, Qatar., Salim Khan S; Department of Gastroenterology and Hepatology, Ambulatory Care Center, Hamad Medical Corporation, Doha 3050, Qatar.
Jazyk: angličtina
Zdroj: Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology [Arab J Gastroenterol] 2024 Jul 29. Date of Electronic Publication: 2024 Jul 29.
DOI: 10.1016/j.ajg.2024.07.007
Abstrakt: Background and Study Aim: Helicobacter Pylori (H. pylori), a widespread gastric pathogen, can have a range of presentations necessitating population based tailored treatment strategies. We aimed to study the clinical and demographic profile of patients with H pylori in Qatar, to determine the best treatment strategy for Qatar's population.
Patients and Methods: Retrospective data collection of all patients diagnosed with H pylori from January 2017 to December 2019 in Hamad Medical Corporation (HMC) and Primary Health Care Corporation (PHCC), Qatar was done. The demographic, clinical, endoscopic and histologic characteristics of patients and H. Pylori directed therapies were documented and compared. Pearson's Chi-square test, independent samples ttest or analysis of variance (ANOVA) was used as appropriate to compare various parameters between patients.
Results: 2217 patients tested positive for H. Pylori over 3 yrs. of which 837 (37.8 %) were Qatari nationals. Dyspepsia was the most common indication for testing (44.6 % patients) which was positively associated with gastric erythema and atrophy on endoscopy (P = 0.000 and 0.004, respectively) and negatively associated with a normal endoscopy (p = 0.038). Most of the patients had chronic active gastritis (98.2 %). Other pre-malignancies were seen in only 85 (14.3 %) patients. Mean (SD) age of patients with premalignancies was significantly more than those without [ 53.25 (17.6) vs. 44.77 (14.8), p = 0.000]. Only 11(0.6 %) patients had a malignancy of the stomach.
Conclusion: H pylori infection may be quite prevalent amongst Qatari nationals. Since prevalence of gastric premalignancies and incidence of gastric malignancy in patients with H pylori in Qatar may be low, generalized test and treat strategy is not economically and practically meaningful in Qatar. Symptomatic patients should be tested and treated, with endoscopy reserved for those with alarming symptoms, failure of proton pump inhibitors and older patients.
Competing Interests: Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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