Pre-existing immunity to influenza aids ferrets in developing stronger and broader H3 vaccine-induced antibody responses.

Autor: Ge Y; School of Health Professions, University of Southern Mississippi, Hattiesburg 39402, MS, USA., Lu Y; Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens 30602, GA, USA., Allen JD; Cleveland Clinic, Florida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA., Einav T; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA., Nkaleke DI; School of Health Professions, University of Southern Mississippi, Hattiesburg 39402, MS, USA., Bai F; School of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg 39402, MS, USA., Handel A; Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens 30602, GA, USA., Ross TM; Cleveland Clinic, Florida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA; Center for Vaccines and Immunology, The University of Georgia, Athens 30606, GA, USA; Cleveland Clinic, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44106, USA., Shen Y; Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens 30602, GA, USA. Electronic address: yeshen@uga.edu.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Aug 30; Vol. 42 (21), pp. 126149. Date of Electronic Publication: 2024 Jul 29.
DOI: 10.1016/j.vaccine.2024.07.050
Abstrakt: Influenza seasons occur annually, building immune history for individuals, but the influence of this history on subsequent influenza vaccine protection remains unclear. We extracted data from an animal trial to study its potential impact. The trial involved 80 ferrets, each receiving either one type of infection or a placebo before vaccination. We quantified the vaccine protection by evaluating hemagglutination inhibition (HAI) antibody titer responses. We tested whether hosts with different infection histories exhibited similar level of responses when receiving the same vaccine for all homologous and heterologous outcomes. We observed that different pre-existing immunities were generally beneficial to vaccine induced responses, but varied in magnitude. Without pre-immunity, post-vaccination HAI titers after the 1st dose of the vaccine were less likely to be above 1:40, and a booster shot was needed. Our study suggests that pre-existing immunity may strengthen and extend the homologous and heterologous vaccine responses.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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