Rhodium-Catalyzed Regioselective [4 + 2] Cycloaddition of Ynamines and 2-(Cyanomethyl)phenylboronates.
| Autor: | Xie ZY; College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China., Tang C; College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China., Li L; College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China., Zhou Z; Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China., Zou J; School of Science, Shanghai Institute of Technology, Shanghai, 201418, China., Qian PC; College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China.; College of Medicine & Pharmaceutical Enginering, Taizhou Vocational & Technical College, Taizhou 318000, China. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2024 Aug 09; Vol. 26 (31), pp. 6586-6590. Date of Electronic Publication: 2024 Jul 30. |
| DOI: | 10.1021/acs.orglett.4c02120 |
| Abstrakt: | A rhodium-catalyzed [4 + 2] cycloaddition of ynamines and 2-(cyanomethyl)phenylboronates has been developed, leading to efficient and excellent regioselective synthesis of valuable indole-linked aromatic compounds in a concise and flexible approach. Interestingly, this strategy was successful in the construction of C···N axially chiral indoles with high enantiocontrol by the introduction of a new phosphoramidite ligand (Xie-Phos). |
| Databáze: | MEDLINE |
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