Association between interpregnancy interval and adverse perinatal outcomes among subsequent twin pregnancies: a nationwide population-based study.

Autor: Ye S; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Huang X; Medical Administration Division, People's Hospital of Huadu District, Guangzhou, Guangdong, China (Huang)., Fan D; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Chen G; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Li P; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Rao J; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Zhou Z; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Guo X; Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Liu Z; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin)., Lin D; Foshan Institute of Fetal Medicine, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Liu, Lin); Department of Obstetrics, Maternal & Child Health Hospital of Foshan, Foshan, Guangdong, China (Ye, Fan, Chen, Li, Rao, Zhou, Guo, Liu, Lin). Electronic address: lindongxin21@outlook.com.
Jazyk: angličtina
Zdroj: American journal of obstetrics & gynecology MFM [Am J Obstet Gynecol MFM] 2024 Sep; Vol. 6 (9), pp. 101439. Date of Electronic Publication: 2024 Jul 28.
DOI: 10.1016/j.ajogmf.2024.101439
Abstrakt: Background: The existing evidence on the association between interpregnancy interval (IPI) and pregnancy outcomes primarily focuses on singleton pregnancies, with limited research on twin pregnancies.
Objective: This study aimed to investigate the association between IPI and adverse perinatal outcomes in twin pregnancies.
Study Design: This population-based, retrospective cohort study analyzed data from the National Center for Health Statistics in the United States between 2016 and 2020. We included multiparous women aged 18 to 45 years with live-born twins without congenital anomalies, born between 26 and 42 weeks of gestation. Poisson regression models, adjusted for potential confounders, were used to evaluate the associations between IPI and adverse outcomes, including preterm birth (PTB) <36 weeks, small for gestational age (SGA), neonatal intensive care unit (NICU) admission, neonatal composite morbidity, and infant death. Missing data on covariates were managed using multiple imputations. Dose-response analyses were performed using the restricted cubic splines (RCS) approach. Subgroup analyses were stratified by maternal age, parity, and combination of neonatal sex. Sensitivity analyses were conducted using complete data and excluding pregnancies with intervening events during the IPI.
Results: A total of 143,014 twin pregnancies were included in the analysis. Compared to the referent group (IPI of 18-23 months), an IPI of less than 6 months was associated with an increased risk of PTB<36 weeks (RR, 1.21; 95% confidence interval [95% CI]: 1.17-1.25), SGA (RR, 1.11; 95% CI: 1.03-1.18), neonatal composite morbidity (RR, 1.19; 95% CI: 1.12-1.27), NICU admission (RR, 1.18; 95% CI: 1.14-1.22), and infant death (RR, 1.29; 95% CI: 1.05-1.60). An IPI of 5 years or more was associated with an increased risk of PTB<36 weeks (RR, 1.18; 95% CI: 1.15-1.21), SGA (RR, 1.24; 95% CI: 1.18-1.30), neonatal composite morbidity (RR, 1.10; 95% CI: 1.05-1.15), and NICU admission (RR, 1.14; 95% CI: 1.11-1.17). The dose-response analyses showed that these outcomes had U-shaped or J-shaped associations with IPI. The associations between IPI and the outcomes slightly differed by advanced maternal age, parity, and combination of neonatal sex. The sensitivity analyses yielded similar results to the main findings.
Conclusion: Extreme IPI, less than 6 months or more than 5 years, was associated with adverse outcomes in twin pregnancies. IPI could be used as a predictor for risk stratification in high-risk twin pregnancies.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: