Comorbidity and sex differences in functional disorders and internalizing disorders.

Autor: Thomas NS; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA. Electronic address: nate.thomas@vcuhealth.org., Gillespie NA; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA., Kendler KS; Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA., Oldehinkel AJ; University of Groningen, University Medical Center Groningen, Department of Psychiatry, P.O. Box 30.001, 9700, RB, Groningen, Netherlands., Rosmalen JGM; University of Groningen, University Medical Center Groningen, Department of Psychiatry, P.O. Box 30.001, 9700, RB, Groningen, Netherlands; University of Groningen, University Medical Center Groningen, Department of Internal Medicine, P.O. Box 30.001, 9700, RB, Groningen, Netherlands., van Loo HM; University of Groningen, University Medical Center Groningen, Department of Psychiatry, P.O. Box 30.001, 9700, RB, Groningen, Netherlands.
Jazyk: angličtina
Zdroj: General hospital psychiatry [Gen Hosp Psychiatry] 2024 Sep-Oct; Vol. 90, pp. 91-98. Date of Electronic Publication: 2024 Jul 26.
DOI: 10.1016/j.genhosppsych.2024.07.013
Abstrakt: Objective: In the current exploratory study we estimate comorbidity rates between FDs [fibromyalgia (FM), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and irritable bowel syndrome (IBS)]-and IDs-[major depressive disorder (MDD) and generalized anxiety disorder (GAD)] by using self-reported diagnostic criteria.
Method: We analyzed data from 107,849 participants (mean age = 49.3 (SD = 13.0), 58.6% women) of the Lifelines Cohort Study. Lifelines is a prospective population-based cohort study in the northeast of the Netherlands. Current IDs were assessed using the Mini-International Neuropsychiatric Interview. Current FM, ME/CFS, and IBS were assessed according to the 2010 American College of Rheumatology criteria, the 1994 Centers for Disease Control and Prevention criteria and the ROME IV criteria, respectively. We estimated tetrachoric correlations between diagnoses and tested for sex differences. Additionally, we estimated the ratio of observed-to-expected frequency for combinations of diagnoses.
Results: FDs and IDs are highly comorbid (odds ratios: 3.2-12.6) with associations stronger among men. Participants with at least three disorders/diagnoses were more prevalent than expected by chance.
Conclusion: Studies that aim to explain sex differences and the comorbidity of specific combinations of IDs and FDs will be an important contribution to understanding the etiology of these conditions.
Competing Interests: Declaration of competing interest Nathaniel S. Thomas, Nathan A. Gillespie, Kenneth S. Kendler, Albertine J. Oldehinkel, Judith G.M. Rosmalen and Hanna M. van Loo declare that they have no conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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