La Crosse virus encephalitis in children.
| Autor: | Ouellette CP; Division of Infectious Diseases and Host Defense Program, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in infectious diseases [Curr Opin Infect Dis] 2024 Oct 01; Vol. 37 (5), pp. 419-424. Date of Electronic Publication: 2024 Jul 24. |
| DOI: | 10.1097/QCO.0000000000001042 |
| Abstrakt: | Purpose of Review: La Crosse virus encephalitis (LACV-E) is among the most common neuroinvasive arthropod-borne viral infections of childhood in North America. Children are uniquely predisposed to symptomatic disease, whereas symptomatic adult infections remain uncommon. Infection results frequently in neurologic symptomatology including headaches, seizures, and altered mentation, often necessitating hospitalization and significant diagnostic evaluation. The purpose of this review is to provide a contemporary assessment of clinical, laboratory, and neurobehavioral outcomes of children with LACV-E. Recent Findings: Common clinical manifestations at presentation, specifically seizure activity and altered mental status, are independent predictors of disease severity. Epileptiform discharges on electroencephalogram (EEG) during hospitalization may predict long-term epilepsy diagnosis. Lastly, long-term neurologic sequelae from acute infection is persistent and likely under-recognized among children with LACV-E. Summary: As climate change alters the geographic distribution of mosquito borne illnesses, a possibility of regional expansion of La Crosse virus (LACV) endemicity exists. The above data highlight readily identifiable features and testing modalities for clinicians who may encounter this viral infection. Importantly, an emphasis on long term neurobehavioral follow up is necessary to better identify and provide support of affected individuals. Future research in identifying host immune responses to LACV infection, as well as therapeutic options, are needed. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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