Efficacy of therapeutic-dose heparin for severe COVID-19 patients at COVID-19 Emergency Hospital Jakarta.

Autor:	Hendarto H; Department of Internal Medicine, Faculty of Medicine, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Banten, 15419, Indonesia., Akbar FN; Department of Internal Medicine, Faculty of Medicine, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Banten, 15419, Indonesia., Buwono PW; Department of Internal Medicine, Faculty of Medicine, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Banten, 15419, Indonesia., Yasmin PA; Faculty of Medicine, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Banten, Indonesia., Halida M; Department of Anaesthesiology and Intensive Care, The National COVID-19 Emergency Hospital Wisma Atlet Kemayoran Jakarta 10620, Indonesia., Ismail E; Department of Pulmonology, The National COVID-19 Emergency Hospital Wisma Atlet Kemayoran Jakarta 10620, Indonesia., Rakhmawati N; Department of Neurology, The National COVID-19 Emergency Hospital Wisma Atlet Kemayoran Jakarta, 10620, Indonesia., Tadjoedin H; Department of Internal Medicine-Haematology-Oncology Division, Dharmais Cancer Hospital Jakarta Jakarta,11420, Indonesia.
Jazyk:	angličtina
Zdroj:	Journal of infection in developing countries [J Infect Dev Ctries] 2024 Jul 29; Vol. 18 (7), pp. 1002-1009. Date of Electronic Publication: 2024 Jul 29.
DOI:	10.3855/jidc.18966
Abstrakt:	Introduction: Arterial and venous thrombotic events in COVID-19 cause significant morbidity and mortality. For optimal thromboprophylaxis treatment for hospitalized patients, especially those with severe COVID-19 symptoms, it is still unclear whether to use full- or therapeutic-dose versus prophylactic-dose anticoagulation therapy. The study aim was to evaluate the efficacy and safety of unfractionated heparin (UFH) for thromboprophylaxis in severe degree of COVID-19. Methodology: In this cross-sectional study, the medical records of 160 COVID-19 patients at the COVID-19 Emergency Hospital Wisma Atlet, Jakarta, from March to August 2021, were collected. The predetermined inclusion criteria for patients were severe COVID-19 infection; age > 18 years; positive D-dimer level > 400 ng/mL; high-flow nasal cannula (HFNC) oxygenation; IMPROVE bleeding risk score < 7; and willingness to participate in the study. The primary outcome was activated partial thromboplastin time (APTT) target achievement, oxygenation changed to nasal cannula or ended with room air, mortality rate, and the principal safety criterion was presence of bleeding. Results: Of 160 subjects, 63.8% were male and 45.6% were aged 45-59 years old. Obesity was the most common comorbidity at 45.6% Among all subjects, 9.4% experienced bleeding, with hematuria being the most frequent type at 66.7%. All subjects released HFNC, and no deaths were reported. Conclusions: It can be concluded that administration of therapeutic doses of heparin in patients with severe COVID-19 had a low risk of bleeding and no patients were reported to have died. However, further investigation is needed to determine the long-term effects of therapeutic doses of anticoagulants. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2024 Hari Hendarto, Femmy Nurul Akbar, Prasetyo Widhi Buwono, Putri Adara Yasmin, Mega Halida, Efriadi Ismail, Nurul Rakhmawati, Hilman Tadjoedin.)
Databáze:	MEDLINE
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