An intense 60-day weight-loss course leads to an 18 kg body weight reduction and metabolic reprogramming of soldiers with obesity.

Autor:	Albores-Méndez EM; Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Secretaría de la Defensa Nacional, Mexico City, Mexico., Carrasco-Vargas H; Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Secretaría de la Defensa Nacional, Mexico City, Mexico., Alaniz Monreal S; Universidad Anáhuac, Huixquilucan, Mexico., Mayen Quinto RD; Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Secretaría de la Defensa Nacional, Mexico City, Mexico., López García ED; Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Secretaría de la Defensa Nacional, Mexico City, Mexico., Gutierrez Salmean G; Universidad Anáhuac, Huixquilucan, Mexico., Medina-Quero K; Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Secretaría de la Defensa Nacional, Mexico City, Mexico., Vargas-Hernández MA; Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Secretaría de la Defensa Nacional, Mexico City, Mexico., Ferreira Batista CV; Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos, Secretaría de la Defensa Nacional, Mexico City, Mexico., López-Hernández Y; Laboratorio de Proteómica y Metabolómica de la Unidad de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas, Mexico., Winkler R; Unidad de Genómica Avanzada, Cinvestav, Irapuato, Mexico.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2024 Jul 26; Vol. 12, pp. e17757. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
DOI:	10.7717/peerj.17757
Abstrakt:	Soldiers of the Mexican Army with obesity were subjected to an intense 60-day weight-loss course consisting of a controlled diet, daily physical training, and psychological sessions. The nutritional treatment followed the European Society of Cardiology (ESC) recommendations, incorporating elements of the traditional milpa diet in the nutritional intervention. The total energy intake was reduced by 200 kcal every 20 days, starting with 1,800 kcal and ending with 1,400 kcal daily. On average, the participants reduced their body weight by 18 kg. We employed an innovative approach to monitor the progress of the twelve soldiers who completed the entire program. We compared the untargeted metabolomics profiles of their urine samples, taken before and after the course. The data obtained through liquid chromatography and high-resolution mass spectrometry (LC-MS) provided insightful results. Classification models perfectly separated the profiles pre and post-course, indicating a significant reprogramming of the participants' metabolism. The changes were observed in the C1-, vitamin, amino acid, and energy metabolism pathways, primarily affecting the liver, biliary system, and mitochondria. This study not only demonstrates the potential of rapid weight loss and metabolic pathway modification but also introduces a non-invasive method for monitoring the metabolic state of individuals through urine mass spectrometry data. Competing Interests: Robert Winkler is an Academic Editor of PeerJ and a Section Editor of PeerJ Plant Biology. (©2024 Albores-Méndez et al.)
Databáze:	MEDLINE
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