FDG uptake of pulmonary lesions in synchronous primary lung cancers and lung metastases.

Autor: Karpinski S; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada., Al Bimani Z; Nuclear Medicine and Molecular Imaging Center, Royal Hospital, Muscat, Oman., Dobson JL; Department of Diagnostic Radiology, Dalhousie University, Halifax, Nova Scotia, Canada., Zeng W; Department of Medicine, Division of Nuclear Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada.
Jazyk: angličtina
Zdroj: Research in diagnostic and interventional imaging [Res Diagn Interv Imaging] 2024 Mar 08; Vol. 9, pp. 100041. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
DOI: 10.1016/j.redii.2024.100041
Abstrakt: Purpose: In lung cancer patients, the distinction between synchronous primary lung cancer and intrapulmonary metastasis can be challenging. The intensity of FDG uptake in pulmonary lesions has been shown to be potentially useful in classifying synchronous lung cancer. The aim of this retrospective study is to investigate the effectiveness of FDG uptake in differentiating metastases from synchronous primary lesions in the setting of lung cancer.
Methods: Consecutive patients with primary lung cancer with two or more malignant lung lesions referred for ( 18 F)-FDG PET-CT imaging between 2010 and 2019 were reviewed and classified into synchronous and metastasis groups. Lesional maximum standardized uptake values (SUV max ), relative differences in SUV max and SUV max ratios were calculated and compared using receiver operating characteristic (ROC) curve analysis. Intra-group correlation in SUV max between lesion pairs was examined using Pearson's and Spearman's correlation analysis.
Results: 94 patients were included for analysis, divided into synchronous ( n = 62; 68 lesion pairs) and metastasis ( n = 32; 33 lesion pairs) groups. The correlation of FDG uptake between lesions in the metastasis group was strong ( r = 0.81). A significant difference in mean relative difference in SUV max (synchronous: 0.50±0.23 metastasis: 0.34±0.17, p = 0.001) and mean SUV max ratio (synchronous: 2.6 ± 1.7 metastasis: 1.7 ± 0.6, p < 0.001) was observed. ROC analysis revealed a fair AUC (0.71-0.72) for these parameters, with an associated sensitivity of 59 % and specificity of 82 % at optimal cut-off values.
Conclusion: Differences in FDG uptake intensity among multiple synchronously presenting malignant nodules may be helpful to distinguish second primary lung tumours from metastatic spread.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Author(s).)
Databáze: MEDLINE
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