Genetic diversity of Leishmania donovani causing visceral and cutaneous leishmaniasis in the Western Ghats, India.

Autor: Fathima PA; Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India., Shah HK; Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India., Sivalaxmi B; Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India., Haritha HA; Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India., Ajithlal PM; Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India., Aiswarya RS; Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India., Saini P; Indian Council of Medical Research- Vector Control Research Centre (Field Station), Kottayam, Kerala, India. Electronic address: prasantasaini09@gmail.com.
Jazyk: angličtina
Zdroj: Gene [Gene] 2024 Nov 30; Vol. 928, pp. 148803. Date of Electronic Publication: 2024 Jul 27.
DOI: 10.1016/j.gene.2024.148803
Abstrakt: The visceral and atypical cutaneous leishmaniasis (VL and CL) caused by Leishmania donovani is an emerging infectious disease in the Western Ghats, Kerala, India. In this study, L. donovani specific kinetoplast minicircle DNA (k-DNA) sequence analysis was conducted to ascertain the genetic variability among the L. donovani isolates from the Western Ghats. Out of 23 CL and 5 VL suspected patient samples, 18 CL and 3 VL tested positive for k-DNA diagnostic PCR. Subsequently, 17 CL and 3 VL samples were found positive for L. donovani specific k-DNA PCR. Although the genetic diversity among the VL and CL isolates was low, there was clear variation from the parasites reported from other countries. The parasites characterized from the current study were more related to those reported from East Africa and India.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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