Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice.

Autor: De Sousa RAL; Physical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Bairro Alto da Jacuba, Diamantina, MG, CEP 39100-000, Brazil.; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil., Diniz-Magalhaes CO; Physical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Bairro Alto da Jacuba, Diamantina, MG, CEP 39100-000, Brazil.; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.; Multicenter Post Graduation Program in Physiological Sciences (PPGMCF), Brazilian Society of Physiology, UFVJM, Diamantina, MG, Brazil., Cruz PP; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.; Post Graduation Program in Health Sciences (PPGCS), UFVJM, Diamantina, MG, Brazil., de Oliveira GHB; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.; Post Graduation Program in Health Sciences (PPGCS), UFVJM, Diamantina, MG, Brazil., Prates JTAC; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.; Post Graduation Program in Health Sciences (PPGCS), UFVJM, Diamantina, MG, Brazil., de Azevedo Ferreira CM; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.; Post Graduation Program in Health Sciences (PPGCS), UFVJM, Diamantina, MG, Brazil., Silva RR; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.; Post Graduation Program in Health Sciences (PPGCS), UFVJM, Diamantina, MG, Brazil., Cassilhas RC; Physical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Rodovia MGT 367 - Km 583, nº 5000, Bairro Alto da Jacuba, Diamantina, MG, CEP 39100-000, Brazil. rcassilhas@yahoo.com.br.; Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício - GENE), UFVJM, Diamantina, MG, Brazil. rcassilhas@yahoo.com.br.; Multicenter Post Graduation Program in Physiological Sciences (PPGMCF), Brazilian Society of Physiology, UFVJM, Diamantina, MG, Brazil. rcassilhas@yahoo.com.br.; Post Graduation Program in Health Sciences (PPGCS), UFVJM, Diamantina, MG, Brazil. rcassilhas@yahoo.com.br.
Jazyk: angličtina
Zdroj: Neuromolecular medicine [Neuromolecular Med] 2024 Jul 29; Vol. 26 (1), pp. 31. Date of Electronic Publication: 2024 Jul 29.
DOI: 10.1007/s12017-024-08798-x
Abstrakt: The aim of this study was to evaluate the effects of swimming in the brain and behavior of young and aged mice. Forty-eight male C57BL/6 J mice were randomly distributed into 4 groups (n = 12 per group, 3 and 18 months old). The subdivision of the groups was: 3 months-SED, 18 months-SED, 3 months-EXE, and 18 months-EXE. SED mice did not swim, while EXE mice performed the physical exercise protocol. Training was initiated 48 h after the adaptation week. Swimming sessions consisted of 30 min, with no overload, 5 days per week, for 4 weeks. After the exercise protocol, it was revealed working and spatial memory were impaired in the 18 months-SED group. Pre- and post-synaptic proteins were enhanced in the groups that swam when compared to the 3- and 8 months-SED groups. Lipid peroxidation was greater in the aged mice that did not perform the physical exercise protocol and might have contributed to the cognitive impairment in this group. In conclusion, an aerobic physical exercise protocol, performed through regular swimming sessions, inhibited cognitive impairment, memory loss and lipid peroxidation in the aged mice, while pre- and post-synaptic proteins were enhanced in the hippocampus of young and aged mice.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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