Essential Oil and Waste Hydrosol of Ocimum Tenuiflorum L.: A Low-Cost Raw Material Source of Eugenol, Botanical Pesticides, and Therapeutic Potentiality.

Autor: Giang Le D; Department of Chemistry, Vinh University, 43000, Nghe An, Vietnam., Satyal P; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, 84043, Lehi, UT, USA., Giang Nguyen H; Department of Chemistry, Vinh University, 43000, Nghe An, Vietnam., Nhi Nguyen TU; Department of Chemistry, Vinh University, 43000, Nghe An, Vietnam., Nhung Nguyen C; Department of Chemistry, Vinh University, 43000, Nghe An, Vietnam., Hang Le T; Department of Chemistry, Vinh University, 43000, Nghe An, Vietnam., Huynh Le V; Department of Chemistry, Vinh University, 43000, Nghe An, Vietnam., Luong Ngo X; Department of Natural Sciences, Hong Duc University, 40000, Thanh Hoa, Vietnam., Hoa Le TM; Department of Pharmacy, Vinh Medical University, 43000, Nghe An, Vietnam., Hoa Vo V; Department of Pharmacy, Duy Tan University, 03 Quang Trung, 550000, Da Nang, Vietnam., Thuong Vo T; Department of Pharmacy, Duy Tan University, 03 Quang Trung, 550000, Da Nang, Vietnam., Hung Nguyen H; Department of Pharmacy, Duy Tan University, 03 Quang Trung, 550000, Da Nang, Vietnam.; Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, 03 Quang Trung, 550000, Da Nang, Vietnam., Hung Nguyen V; Faculty of Natural Sciences, Dong Thap University, 81000, Dong Thap, Vietnam., Setzer WN; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, 84043, Lehi, UT, USA.; Department of Chemistry, University of Alabama in Huntsville, 35899, Huntsville, AL, USA.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Nov; Vol. 21 (11), pp. e202401161. Date of Electronic Publication: 2024 Sep 24.
DOI: 10.1002/cbdv.202401161
Abstrakt: In this study, essential oils and waste hydrosols of leaves of Ocimum tenuiflorum in four different geographical locations were extracted by hydrodistillation method and using gas chromatography/mass spectrometry (GC/MS) for chemical composition analysis. All four essential oil samples contained the main components (E)-β-caryophyllene (27.8-49.0 %), trans-β-elemene (20.3-37.1 %) and eugenol (9.0-44.0 %). Three of the four hydrosol samples had eugenol in absolute content (94.5-98.6 %), while the remaining hydrosol sample had two main components, elemicin (77.8 %) and eugenol (14.2 %). Essential oils and hydrosols demonstrated larvicidal activities against four important disease-transmitting mosquito species including Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Culex fuscocephala with 24-h LC 50 values in the range 15.42-56.01 μg/mL and 53.88-97.80 μg/mL for the essential oils and the hydrosols, respectively. Essential oils and hydrosols strongly inhibited the acetylcholinesterase (AChE) enzyme of electric eels with IC 50 values in the range of 25.35-107.19 μg/mL. Microemulsion (ME) can be considered as a sustainable pesticide formulation over 300 days and has improved larvicidal activity compared to free essential oil. The O. tenuiflorum in Vietnam can be considered a low-cost source of eugenol, botanical pesticides that control disease-transmitting mosquitoes, as well as having therapeutic potential to be further investigated.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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