A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures.

Autor: Ooga M; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp., Sahayasheela VJ; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp., Hirose Y; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp., Sasaki D; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp., Hashiya K; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp., Bando T; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp., Sugiyama H; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan. hs@kuchem.kyoto-u.ac.jp.
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Aug 13; Vol. 60 (66), pp. 8744-8747. Date of Electronic Publication: 2024 Aug 13.
DOI: 10.1039/d4cc01572j
Abstrakt: G-quadruplex (G4) structures play roles in various biological processes, but the challenge lies in specific targeting. To address this, we synthesized a conjugate capable of recognizing the G4 structure and its proximal duplex. Our conjugate can enable recognition of specific G4s in the human genome to understand and target those structures.
Databáze: MEDLINE
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