The Impact of Anemia on the Survival of Patients Diagnosed With Low-Grade Malignant B-cell Lymphomas.

Autor:	Mondoc LM; Hematology, Sibiu County Emergency Clinical Hospital, Sibiu, ROU.; Physiopathology, Faculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, ROU., Catana AC; Hematology, Sibiu County Emergency Clinical Hospital, Sibiu, ROU.; Hematology, Faculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, ROU., Prodan LC; Neurology, Sibiu County Emergency Clinical Hospital, Sibiu, ROU.; Physiopathology, Faculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, ROU., Valeanu M; Biostatistics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Cluj-Napoca, ROU., Mihaila RG; Hematology, Sibiu County Emergency Clinical Hospital, Sibiu, ROU.; Hematology, Faculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, ROU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 26; Vol. 16 (7), pp. e65441. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
DOI:	10.7759/cureus.65441
Abstrakt:	Introduction: B-cell lymphomas with a low degree of malignancy represent a heterogeneous group of diseases, that evolve slowly, but present particularities in terms of long-term survival. Methods: We investigated the impact of anemia from the time of diagnosis in 249 patients with malignant B-cell lymphomas, diagnosed between January 2011 and December 2015, in the Hematology Department of the Sibiu County Emergency Hospital, Romania. Results: We included 126 (50.6%) male and 123 (49.4%) female patients with the average age being 68.2 years. Among all patients, 106 (42.6%) were diagnosed with chronic lymphocytic leukemia (CLL), 61 (24.5%) with marginal zone lymphoma (MZL), 53 (21.3%) with multiple myeloma (MM), 16 (6.4%) with follicular lymphoma (FL), nine (3.6%) with plasmacytoma, and four cases with hairy cell leukemia (HCL). The serum Hb value in the subject group varied between 2.6 g/dL and 17 g/dL. At diagnosis, 18 (7.2%) patients had severe anemia, 32 (12.9%) had moderate anemia, 58 (23.3%) had mild anemia, and 141 (56.6%) had no anemia at all at the time of diagnosis. In our group, the higher degree of anemia was correlated with a more advanced stage of the disease but not with the older age of the patients. Our study's highest median value of LDH corresponded to moderate anemia and the lowest value to patients who did not have anemia. Patients who did not have anemia at diagnosis had the best survival at five years, followed by those with mild anemia, then those with moderate anemia. Conclusion: In our cohort, subjects with the lowest Hb value at diagnosis had the worst survival. The results of our study conclude that anemia represents a negative impact factor not only on the patient's quality of life but also on their survival. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Ethics, Medical Deontology and Discipline Commission of the Sibiu County Emergency Clinical Hospital issued approval N/A. The commission gave a favorable report for conducting the retrospective study in the Sibiu County Emergency Clinical Hospital. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Mondoc et al.)
Databáze:	MEDLINE
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