A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.

Autor:	Wang H; Brigham and Women's Hospital., Nagarajan P, Winkler T, Bentley A; National Institutes of Health, NHGRI., Miller C, Kraja A, Schwander K, Lee S, Wang W, Brown M; The University of Texas Health Science Center at Houston., Morrison J, Giri A, O'Connell J, Bartz T, de Las Fuentes L; Washington University School of Medicine., Gudmundsdottir V, Guo X; The Lundquist Institute., Harris S; The University of Edinburgh., Huang Z, Kals M, Kho M, Lefevre C, Luan J; University of Cambridge., Lyytikäinen LP; Fimlab Laboratories and Finnish Cardiovascular Research Center., Mangino M; King's College London., Milaneschi Y; VU University Medical Center., Palmer N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai., Rao V, Rauramaa R, Shen B, Stadler S, Sun Q; University of North Carolina, USA., Tang J, Thériault S, van der Graaf A, van der Most P, Wang Y, Weiss S; University Medicine Greifswald & University of Greifswald., Westerman K, Yang Q, Yasuharu T, Zhao W; University of Michigan., Zhu W, Altschul D, Ansari MAY, Anugu P, Argoty-Pantoja A, Arzt M, Aschard H; Institut Pasteur., Attia J, Bazzano L; Louisiana State University., Breyer M, Brody J, Cade B; Brigham and Women's Hospital., Chen HH; Vanderbilt University Medical Center., Chen YI, Chen Z, de Vries P; Human Genetics Center., Dimitrov L, Do A, Du J, Dupont C, Edwards T, Evans M; National Institute on Aging., Faquih T, Felix S, Fisher-Hoch S, Floyd J, Graff M; University of North Carolina., Charles Gu C; Washington University., Gu D, Hairston K, Hanley A, Heid I; University of Regensburg., Heikkinen S; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus., Highland H; University of North Carolina at Chapel Hill., Hood M, Kähönen M; Tampere University., Karvonen-Gutierrez C, Kawaguchi T, Kazuya S, Tanika K; University of Illinois Chicago., Komulainen P, Levy D, Lin H, Liu P, Marques-Vidal P, McCormick J; The University of Texas Health Science Center at Houston (UTHealth) School of Public Health., Mei H; University of Mississippi Medical Center., Meigs J, Menni C; King's College London., Nam K; Seoul National University., Nolte I; University of Groningen, University Medical Center Groningen., Pacheco N, Petty L, Polikowsky H, Province M; Washington University., Psaty B; Cardiovascular Health Research Unit., Raffield L, Raitakari O; Turku University Hospital and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku., Rich S; University of Virginia., Riha R, Risch L, Risch M, Ruiz-Narvaez E, Scott R; University of Newcastle and the Hunter Medical Research Institute., Sitlani C, Smith J; University of Michigan., Sofer T; Harvard University., Teder-Laving M, Völker U; University Medicine Greifswald., Vollenweider P; Lausanne University Hospital (CHUV)., Wang G, van Dijk KW; Leiden University Medical Center., Wilson O, Xia R; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston., Yao J, Young K, Zhang R, Zhu X; Case Western Reserve University., Below J; Vanderbilt University Medical Center., Böger C, Conen D, Cox S; University of Edinburgh., Dörr M; University Medicine Greifswald., Feitosa M; Washington University School of Medicine., Fox E, Franceschini N, Gharib S; University of Washington., Gudnason V; Icelandic Heart Association., Harlow S, He J; Tulane University School of Public Health and Tropical Medicine., Holliday E; Hunter Medical Research Institute., Kutalik Z, Lakka T, Lawlor D; University of Bristol., Lee S, Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University., Li C; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Liu CT; Boston University School of Public Health., Mägi R, Matsuda F, Morrison A; The University of Texas Health Science Center at Houston., Penninx BWJH, Peyser P; Department of Epidemiology, School of Public Health, University of Michigan., Rotter J; The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center., Snieder H; University Medical Center Groningen., Spector T, Wagenknecht L, Wareham N; University of Cambridge., Zonderman A; National Institute on Aging, NIA/NIH/IRP., North K; UNC Chapel Hill., Fornage M; 1. Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center.; 2. Human Genetics Center, Department of Epidemiology, School of Public Health., Hung A, Manning A, Gauderman W, Chen H, Munroe P, Rao D; Washington University in St. Louis., van Heemst D, Redline S; Brigham and Women's Hospital., Noordam R; Leiden University Medical Center.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2024 Jul 17. Date of Electronic Publication: 2024 Jul 17.
DOI:	10.21203/rs.3.rs-4163414/v1
Abstrakt:	Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management. Competing Interests: Declarations CONFLICT OF INTEREST C.L.M. has received funding from AstraZeneca not related to the current study. B.M.P. serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. D.C. receives consultancy fees from Roche Diagnostics and Trimedics and speaker fees from Servier. D.A.L. has received support from Medtronic LTD and Roche Diagnostics for biomarker research not related to the current study. The remaining authors declare no competing interests.
Databáze:	MEDLINE
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