Protumorigenic Interferon-Stimulated Genes in Cancer: A Comprehensive Review.

Autor:	Butt DQ; Oral Medicine and Oral Pathology Unit, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS., Harun MH; Oral Medicine and Oral Pathology Unit, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS., Che Jalil NA; Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS., Shamsuddin SH; Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS., Jaafar S; Basic Sciences Unit, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS., Ahmad B; Biostatistics Unit, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 26; Vol. 16 (6), pp. e63216. Date of Electronic Publication: 2024 Jun 26 (Print Publication: 2024).
DOI:	10.7759/cureus.63216
Abstrakt:	Interferon-stimulated genes (ISGs), whose production is triggered by interferons, are known to defend the host from pathogenic and cancer-specific antigens, one of which is by inducing apoptosis in infected or mutated cells. It has been reported recently that specific ISGs aid cancer cells in evading immunosurveillance and inflammatory cells by inhibiting the apoptosis process. This report reviewed four apoptosis-regulating ISG proteins: interferon-stimulated gene 15 (ISG15), interferon alpha-inducible protein 27 (IFI27), interferon alpha-inducible protein 6 (IFI6), and radical S-adenosyl methionine domain containing 2 (RSAD2), demonstrating anti-apoptosis function, and considered them protumorigenic. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Butt et al.)
Databáze:	MEDLINE
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